Clinical DNA Online

The mission of the National Institute of Standards and Technology (NIST) is to serve the clinical and industrial community by advancing measurement science, standards, and technology. One way we do so is by providing primary reference materials, defined as materials that are certified to be traceable to the international system of units (SI).

General Information

The clinical DNA information resource is a reservoir of information for clinical DNA Standard Reference Materials (SRMs) and candidate materials under consideration. The resource includes presentations, publications, and links to NIST clinical DNA-based SRM certificates. Also included are webpages that summarize the purpose for the reference material and the methods used for certification. 

Clinical Publications and PresentationsTo view past publications and presentations, please click here.

Standard Reference Materials (SRMs)

Clinically-relevant DNA-based SRMs

• Cytomegalovirus for DNA Measurements (SRM 2366)
  • SRM Page (view Certificate or purchase SRM 2366)
  • CMV project page
• Huntington's Disease (SRM 2393)
  • SRM Page (view Certificate or purchase SRM 2393)
  • Huntington's Disease project page 

(S)RMs in Progress

• BK and JC viruses 
  • BK and JC viruses project page

Other available DNA-Based SRMs

• Human DNA Quantitation Standard (SRM 2372)
  • SRM Page (view Certificate or purchase SRM 2372)

• Mitochondrial DNA Sequencing (SRM 2392)
  • SRM Page (view Certificate or purchase SRM 2392)

• Mitochondrial DNA Sequencing (Human HL-60 DNA) (SRM 2392-I)
  • SRM Page (view Certificate or purchase SRM 2392-I)

• PCR-Based DNA Profiling (SRM 2391c)
  • View Certificate or purchase SRM 2391c

• Human Y-Chromosome DNA Profiling (SRM 2395)
  • View Certificate or purchase SRM 2395

Please feel free to contact our group with comments and/or suggestions for reference materials or ideas for measurement collaborations using digital PCR or next-generation sequencing.