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Assuring the Accuracy of Metabolite Measurement and Identification
Reference Material 8231 Frozen Human Plasma Suite for Metabolomics
RM 8231 - Frozen Human Plasma Suite for Metabolomics
This reference material is intended to be used as quality assurance/quality control material for laboratory metabolomic measurements. Products of metabolism act as a fingerprint for cellular processes. Metabolites give insight into the physiology of the cell and can subsequently provide a greater understanding of an organism’s health. Labs that study metabolomics benefit from a characterized complex human sample to assess the performance of their workflows and allow for interlaboratory comparisons.
RM 8231 was created as a suite of phenotypically distinct human plasma. Pooled Plasma 1, Diabetic Plasma: This specific plasma pool was designed to represent a Type 2 diabetic plasma material with glucose >126 mg/dL and low/normal triglyceride (<150 mg/dL). Pooled Plasma 2, Hypertriglyceridemic Plasma: This specific plasma pool was designed as a hypertriglyceridemic plasma material with glucose <100 mg/dL and triacylglycerols >300 mg/dL. Pooled Plasma 3, African-American Plasma: This specific plasma pool was created as a young (ages 20-25 years of age), African American plasma material.
A unit of RM 8231 consists of two vials each of the three phenotypes: Diabetic Plasma, Hypertriglyceridemic Plasma, and African‑American Plasma pools. Each vial contains approximately 1.0 mL of frozen human plasma.