Zhang, K.
, Washburn, N.
and Simon, C.
(2005),
Three-Dimensionally Ordered Macroporous Sol-Gel Bioactive Glass (3DOM-BG) Particles and Their In Vitro Biocompatibility, Biomaterials, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=852406
(Accessed November 9, 2024)
Official websites use .gov
A .gov website belongs to an official government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.
Three-Dimensionally Ordered Macroporous Sol-Gel Bioactive Glass (3DOM-BG) Particles and Their In Vitro Biocompatibility
Published
Author(s)
, N Washburn,
Abstract
Sol-gel bioactive materials are one of the new generation biomaterials that are both bioactive and bioresorbable. The three-dimensionally ordered macroporous (pore size 200-1000 nm) sol-gel bioactive glasses (3DOM-BGs) generate many interesting properties. For example, 3DOM-BGs can quickly and completely convert to calcium-deficient, bone-like apatite in a simulated body fluid (SBF). In this study, 3DOM-BG particles were prepared and characterized. Their in vitro MC3T3-E1 cellular compatibility was tested by the following techniques: (1) Wst-1 assay for cell viability after culture in extracts of 3DOM-BG particles; (2) phase contrast microscopy for cell morphology after culturing in the presence of 3DOM-BG particles; and (3) fluorescence microscopy for imaging cells cultured directly on 3DOM-BG particles. Results demonstrated that 3DOM-BG particles are not cytotoxic and are biocompatible with MC3T3-E1 osteoblasts.Citation
Biomaterials
Volume
26
Pub Type
Journals
Download Paper
Keywords
apatite, bioactive, biocompatibility, biomaterial
Citation
Issues
If you have any questions about this publication or are having problems accessing it, please contact reflib@nist.gov.
Created April 25, 2005, Updated February 17, 2017