Jahn, A.
, Reiner, J.
, Vreeland, W.
, DeVoe, D.
, Locascio, L.
and Gaitan, M.
(2008),
Controlled Encapsulation of a Hydrophilic Drug Simulant in Nano-Liposomes Using Continuous Flow Microfluidics, 11th Annual Nano Science and Technology Institute (NSTI) Nanotech 2008, Boston, MA, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=32987
(Accessed December 26, 2024)
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Controlled Encapsulation of a Hydrophilic Drug Simulant in Nano-Liposomes Using Continuous Flow Microfluidics
Published
Author(s)
, , , Don DeVoe, ,
Abstract
A new method to tailor the size and size distribution of nanometer scale liposomes and control loading of liposomes with a model drug in a continuous-flow microfluidic design is presented. Size and size dispersion are determined with tandem Asymmetric Flow Field Flow Fractionation (AF4) and Multi-Angle Laser Light Scattering (MALLS). Fluorescence Correlation Spectroscopy (FCS) combined with Fluorescence Cumulant Analyis (FCA) allow for determining the number of encapsulated molecules [1]. Results show that this system allows for control of loading efficiency as well as minimization of encapsulant consumption.Proceedings Title
11th Annual Nano Science and Technology Institute (NSTI) Nanotech 2008
Conference Dates
June 1-5, 2008
Conference Location
Boston, MA
Pub Type
Conferences
Download Paper
Keywords
liposomes, encapsulation, fluorescence spectroscopy, hydrodynamic focusing, microfluidics
Citation
Issues
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Created June 4, 2008, Updated February 19, 2017