Smolyanitsky, A.
and Luan, B.
(2021),
Nanopores in Atomically Thin 2D Nanosheets Limit Aqueous Single-Stranded DNA Transport, Physical Review Letters, [online], https://doi.org/10.1103/PhysRevLett.127.138103, https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=931254
(Accessed October 14, 2025)
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Nanopores in Atomically Thin 2D Nanosheets Limit Aqueous Single-Stranded DNA Transport
Published
Author(s)
, Binquan Luan
Abstract
Nanopores in 2D materials are highly desirable for DNA sequencing, yet achieving single-stranded DNA (ssDNA) transport through them is challenging. Using density functional theory calculations and molecular dynamics simulations we show that ssDNA transport through a pore in monolayer hexagonal boron nitride (h-BN) is marked by a basic nanomechanical conflict. It arises from the notably inhomogeneous flexural rigidity of ssDNA and causes high friction via transient DNA desorption costs exacerbated by solvation effects. For a similarly sized pore in bilayer h-BN, its self-passivated atomically smooth edge enables continuous ssDNA transport. Our findings shed light on the fundamental physics of biopolymer transport through pores in 2D materials.Citation
Physical Review Letters
Pub Type
Journals
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Keywords
nanopores, DNA sequencing, theory, simulation, friction
Citation
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Created September 24, 2021, Updated October 14, 2021