Nanofluidics

News and Updates

NIST Scientists Use DNA Origami on a Chip to Detect Biomolecules

October 17, 2024

Using strands of DNA to create miniature hinges that pop open or shut when binding to specific molecules, researchers at the National Institute of Standards and

NIST Researchers Use Cellphone Compass to Measure Tiny Concentrations of Compounds Important for Human Health

April 1, 2024

Nearly every modern cellphone has a built-in compass, or magnetometer, that detects the direction of Earth’s magnetic field, providing critical information for

The FedTech Startup Studio’s Real-World Approach Advances Technology Transfer

March 22, 2023

Technology Transfer is an intensely dynamic field, and the process of moving federal scientific and technological research from the lab to the marketplace teems

Projects and Programs

viral vector illustration with RNA seen within the capsid

Gene Delivery Particle Analysis with High-Throughput Light Scattering Microscopy

Ongoing

This project aims to develop light-scattering microscopy methods for rapid, multi-attribute characterization of gene therapy particles at the single particle level. Emerging gene therapy treatments use gene delivery particles, such as viral vectors and non-viral carriers, to cure intractable

Sensing, Transport, and Simulation

Ongoing

We have recently developed a finite-size scaling approach and special simulation cell aspect ratio—the golden aspect ratio—to enable accurate incorporation of access resistant and bulk diffusion in ionic transport, see the figure. This enables quantitative, and efficient, prediction of ion transport

Schematic showing DNA origami in a laser beam

DNA Origami for Precise Manufacturing of Nanoscale Structures

Completed

The base pairing of adenine to thymine and guanine to cytosine to form DNA provides a robust molecular recognition scheme that can be used to create a wide variety of well-ordered nanostructures. DNA origami, which uses a long scaffold strand folded together by specific sets of short staple strands

Fluctuations and Nanoscale Control Software (Archived)

Completed

For each file YYY.m, type "doc YYY" from the Matlab command prompt for documentation, literature references, and usage guidelines. DSigma2_Est.m Estimates the diffusion coefficient (D) and localization noise (σ 2 or "Sigma2") from single-particle tracking data. It implements the algorithms for the

Publications

Relaxation times and dynamic behavior of an optofluidic flow meter in the nanoliter per minute regime

February 29, 2024

Author(s)

Nicholas Drachman, Paul Patrone, Gregory A. Cooksey

Accuracy and temporal resolution of flow meters are often unacceptable below the microliter per minute scale, limiting their ability to evaluate the real-time

Letter to the Editor Concerning "Simultaneous, Single-Particle Measurements of Size and Loading Give Insights into the Structure of Drug-Delivery Nanoparticles"

May 23, 2023

Author(s)

Andrew Madison, Adam L. Pintar, Craig R. Copeland, Natalia Farkas, Samuel M. Stavis

Chromium Oxide – A Novel Sacrificial Layer Material for MEMS/NEMS and Micro/Nanofluidic Device Fabrication

August 1, 2022

Author(s)

Alokik Kanwal, Robert Ilic, Christopher Ray, Kerry Siebein, James Alexander Liddle

Free standing membranes for fluidic devices typically require long etching times due to the slow, diffusion limited exchange of etchant and etch products when

Optofluidic Flow Meter for sub–nanoliter per minute flow measurements

January 31, 2022

Author(s)

Jalal Sadeghi, Paul Patrone, Anthony J. Kearsley, Gregory A. Cooksey

Performance improvements in microfluidic systems depend on accurate measurement and control of fluids on the micro- and nanoscale, and new applications are