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Displaying 551 - 575 of 837

Predicting Microstructure Development During Casting of Drug Eluting Coatings

September 19, 2010
Author(s)
David M. Saylor, Jonathan E. Guyer, Daniel Wheeler, James A. Warren
We have devised a novel diffuse interface formulation to model the development of chem- ical and physical inhomogeneities, i.e. microstructure, during the process of casting drug eluting coatings. These inhomogeneities, which depend on the coating

Microfluidic Based Contactless DielectrophoreticDevice: Modeling and Analysis

September 1, 2010
Author(s)
Saugandhika Minnikanti, Darwin Reyes-Hernandez, Ruben C. Aguilar, Joseph Pancrazio, Michael Gaitan, Nathalia Peixoto
While there have been many attempts at patterning cells onto substrates, a reliable method for trapping cell clusters and forming cell arrays in a predefined geometry remains to be demonstrated. We intend to develop a multielectrode array platform to

Characterization of gold nanoparticles modified with single-stranded DNA using analytical ultracentrifugation and dynamic light scattering

August 3, 2010
Author(s)
James Falabella, Tae Joon Cho, Dean C. Ripple, Vincent A. Hackley, Michael J. Tarlov
We report the characterization of gold nanoparticles modified with thiol-terminated single stranded DNA using analytical ultracentrifugation and dynamic light scattering. Sedimentation coefficients of nominally 10 and 20 nm diameter gold nanoparticles

Preparation and Characterization of Standard Reference Material 1849 Infant/Adult Nutritional Formula

July 1, 2010
Author(s)
Katherine E. Sharpless, Richard M. Lindstrom, Bryant C. Nelson, Karen W. Phinney, Catherine A. Rimmer, Lane C. Sander, Michele M. Schantz, Rabia Oflaz, Jeanice M. Brown Thomas, Gregory C. Turk, Stephen A. Wise, Laura J. Wood, James H. Yen
Standard Reference Material (SRM) 1849 Infant/Adult Nutritional Formula has been issued by the National Institute of Standards and Technology (NIST) as a replacement for SRM 1846 Infant Formula, which was issued in 1996. Extraction characteristics of SRM

Quantum Dot FRET Sensor for Enzymatic Activity in Microfluidic Device

June 22, 2010
Author(s)
Georgeta Crivat, Sandra M. Da Silva, Darwin Reyes-Hernandez, Samuel Forry, Laurie E. Locascio, Michael Gaitan, Nitsa Rosenzweig, Zeev Rosenzweig
This paper describes the development of new fluorescence resonance energy transfer (FRET)-based quantum dot probes for proteolytic activity. The CdSe/ZnS quantum dots are incorporated into a thin polymeric film, which is prepared by layer-by-layer

FRACTURE OF TOOTH ENAMEL FROM INCIPIENT MICROSTRUCTURAL DEFECTS

June 14, 2010
Author(s)
H Chai, James J. Lee, Brian R. Lawn
We present definitive evidence for crack growth from internal defects called 'tufts' in human enamel. Side walls of slices sawn from extracted human teeth are observed during loading to 'failure'. 'Longitudinal' and 'transverse' slices (parallel and normal

Solutions for Determining Equibiaxial Substrate Strain for Dynamic Cell Culture

May 2, 2010
Author(s)
Martin Y. Chiang, Tianle Cheng, Lisa Pakstis, Joy P. Dunkers
Empirical and analytical solutions are derived in this study to determine the equibiaxial strain on a flexible substrate upon which the cells can be cultured. The empirical formula is based on the mechanistic constraint and a regression analysis of results

Prediction of Collagen and Glycosaminoglycan Content by Acoustic Microscopy

April 21, 2010
Author(s)
Jenni R. Popp, Colm Flannery, Tammy L. Oreskovic, Jennifer Recknor, Kristi S. Anseth, Timothy P. Quinn
Functional tissue engineering of articular cartilage is rapidly advancing as a technique to develop regenerative and reparative treatments for cartilage degeneration and osteoarthritis. Tissue engineered constructs are often developed using a combination

RECIST vs. Volume Measurement in Medical CT Using Ellipsoids of Known Size

April 12, 2010
Author(s)
Zachary H. Levine, Bruce R. Borchardt, Nolan J. Brandenburg, Charles W. Clark, Balasubramanian Muralikrishnan, Craig M. Shakarji, Joseph J. Chen, Eliot L. Siegel
(a) Purpose: We wanted to test the extent to which two common methods of determining the sizes of tumors would perform when compared to a statistically significant number of well-characterized reference objects. The size of the objects was chosen to

Teeth: Among Nature's Most Durable Biocomposites

April 6, 2010
Author(s)
Brian R. Lawn, James J. Lee, H Chai
This paper addresses the durability of natural teeth from a materials perspective. Teeth are depicted as 'smart' biocomposites, highly resistant to cumulative deformation and fracture. Favorable morphological features of teeth at both macroscopic and

Fluorinated Copolymer Nanoparticles for Multimodal Imaging Applications

February 18, 2010
Author(s)
Mark M. Bailey, Christine M. Mahoney, Elodie Dempah, Jeffrey M. Davis, Matthew Becker, Supang Khondee, Eric J. Munson, Cory J. Berkland
Nanomaterials have emerged as valuable tools in biomedical imaging techniques, such as magnetic resonance imaging (MRI), fluorescence, positron emission tomography (PET), and others. Some have been designed to serve as multimodal imaging agents, combining

Microsensors in Dynamic Backgrounds: Toward Real-Time Breath Monitoring

January 15, 2010
Author(s)
Kurt D. Benkstein, Baranidharan Raman, Christopher B. Montgomery, C Martinez, Stephen Semancik
We evaluated MEMS microsensor array with chemi-resistive elements for use as a non-invasive clinical diagnostic tool to detect the presence or absence of trace amounts of disease biomarkers in simulated breath samples. The microsensor environment was

Volumetric CT in Lung Cancer: An Example for the Qualification of Imaging as a Biomarker

January 9, 2010
Author(s)
Charles D. Fenimore, Andrew Buckler, P. David Mozeley, Lawrence H. Schwartz, Nicholas Petrick, Michael McNitt-Gray, Kevin O?Donnell, Wendy Hayes, Hyun Kim, Laurence Clarke, Daniel Sullivan
The Quantitative Imaging Biomarker Alliance (QIBA) has been organized to establish a methodology whereby multiple stakeholders collaborate to test hypotheses about the technical feasibility and the medical value of imaging biomarkers. It has charged the

Gradient Nanofiber Scaffold Libraries for Rapid Screening of Cell-Material Interactions

December 1, 2009
Author(s)
Carl G. Simon Jr., Murugan Ramalingam, Marian F. Young, Vinoy Thomas
Scaffolds play a key role in tissue engineering wherein they provide structural support for cells to adhere, grow and guide them to synthesize tissue. Scaffolds made of multiple biomaterials are typically required to mimic the three-dimensional (3D)

Chemical Science and Technology Laboratory (CSTL) 2009 Annual Report

November 17, 2009
Author(s)
Willie E. May, Richard R. Cavanagh, Dianne L. Poster, Michael D. Amos
CSTL is entrusted with building, sustaining, and maximizing the chemical measurement system that is criticial to chemical technological innovation, economic competitiveness and new job growth for the benefit of the Nation.

Microfabricated multispectral MRI agents: a brief overview

September 3, 2009
Author(s)
Gary Zabow
This paper provides an introductory overview on recent top-down microfabricated, as opposed to traditional bottom-up chemically synthesized, magnetic resonance imaging (MRI) contrast agents. As a specific example of the enhanced agent functionality that

A New 26plex Autosomal STR Assay to Aid Human Identity Testing*(dagger)

September 1, 2009
Author(s)
Carolyn R. Steffen, John M. Butler, Peter Vallone
Multiplex polymerase chain reaction (PCR) has become the standard in forensic testing. Currently there are two commercial multiplex PCR amplification kits available that simultaneously amplify 16 short tandem repeat (STR) loci that include the 13 FBI

Differences in PDMS Modification Affect Laminin Deposition and Smooth Muscle Cell Response

August 16, 2009
Author(s)
Joy P. Dunkers, Hae-Jeong Lee, Marvi Matos, Lisa Pakstis, Juan M. Taboas, Steven D. Hudson, Marcus T. Cicerone
When culturing cells on flexible surfaces, it is important to consider extracellular matrix treatments that will remain on the surface under mechanical strain. Here we investigate differences in laminin surfaces that were deposited on oxidized PDMS (plasma
Displaying 551 - 575 of 837