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Displaying 826 - 850 of 1174

Repair of Formamidopyrimidines in DNA Involves Different Glycosylases - Role of the OGG1, NTH1, and NEIL1 Enzymes

December 9, 2005
Author(s)
J Hu, N de Souza-Pinto, K Haraguchi, Barbara A. Hogue, Pawel Jaruga, M M. Greenberg, Miral M. Dizdar, V. Bohr
2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyG) and 4,6-diamino-5-formamidopyrimidine (FapyA), are formed abundantly in DNA of cultured cells or tissues exposed to ionizing radiation or to other free radical-generating systems. We show here that FapyG

Standards and Standardization of Molecular Diagnostics

August 15, 2005
Author(s)
J P. Jakupciak, C D. O'Connell
DNA has become a major target for clinical laboratory testing over the past 5 years, and RNA testing is emerging for infectious disease and gene expression (1). To normalize laboratory results across different technology platforms as well as between

Mitochondrial DNA as a cancer biomarker

May 1, 2005
Author(s)
J P. Jakupciak, W. Wang, Maura E. Markowitz, D Ally, Michael D. Coble, Sudhir Srivastava, A Maitra, Peter E. Barker, David Sidransky, Catherine D. O'Connell

Standards for Validation of Cancer Biomarkers

April 2, 2005
Author(s)
Catherine D. O'Connell, Donald H. Atha, J P. Jakupciak
Over the past 10 years, DNA testing to identify disease associated mutations and specific organisms, which represent public health and safety concerns, have become major targets for laboratory testing. RNA testing is also emerging for gene expression, both

Infrared and Raman Spectroscopy Characterization of Biological Products

January 1, 2005
Author(s)
Vytautas Reipa
Both infrared and Raman are increasingly applied in biomolecular structure characterization, thus getting acceptance alongside traditional bioanalytical techniques. Physical principles and biological sampling requirements are reviewed. Advanced
Displaying 826 - 850 of 1174