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Displaying 151 - 175 of 1719

Combinatorial Cassettes for Higher-Throughput Screening of Osteogenesis

October 4, 2018
Author(s)
Carl G. Simon Jr., Subhadip Bodhak, Hariharan K. Iyer, Luis Fernandez de Castro Diaz, Pam Robey, Azusa Maeda, Sergei Kuznetsov
Animal models are the most biologically relevant method for measuring the osteogenic capability of bone graft formulations. However, animal experiments are slow, tedious and the results can be highly variable, even when conducted within the same lab. In

Nanoscale Hygromechanical Behavior of Lignin

September 22, 2018
Author(s)
Kristen M. Hess, Jason Killgore, Wil Srubar
The nanoscale hygromechanical behavior of lignin is presented in this work. Three atomic force microscopy experimental methods were used to correlate moisture sorption of lignin to its mechanicalbehavior. First, sorption isotherms were established using

Hierarchical Cellulose Nanocrystal Blends for Bioinspired Damage Tolerant Photonic Films

May 4, 2018
Author(s)
Bharath NMN Natarajan, Ajay Krishnamurthy, Caglar Dogu Emiroglu, Amanda L. Forster, E. J. Foster, Christoph Weder, Douglas M. Fox, Jan Obrzut, Jeffrey W. Gilman
Attempts to emulate strong and tough natural composites using wood cellulose nanocrystals (CNCs) fall short in mechanical performance due to the low shear transfer ability of CNC interfaces in their helicoidal ensembles. This shortcoming is ascribed to the

Cholesterol Functionalized Aliphatic N-Substituted 8 Membered Cyclic Carbonate

April 10, 2018
Author(s)
Vivek M. Prabhu, Shrinivas Venkataraman, Kenneth Mineart, James Hedrick, Yi Yan Yang
Straightforward synthesis of cholesterol functionalized aliphatic N-substituted 8 membered cyclic carbonate monomer is reported. Well-defined PEGylated diblock copolymers were readily accessed via organo catalytic ring opening polymerization. These block

The Evolution of Polystyrene as a Cell Culture Material: A Brief History

April 10, 2018
Author(s)
Max J. Lerman, Josephine Lembong, Shinichiro Muramoto, John G. Gillen, John P. Fisher
Polystyrene (PS) has brought in vitro cell culture from its humble beginnings to the modern era, propelling dozens of research fields along the way. This review discusses the development of the material, fabrication, and treatment approaches to create the

The NISTmAb Reference Material 8671 Value Assignment, Homogeneity, and Stability

March 1, 2018
Author(s)
John E. Schiel, Abigail Turner, Catherine A. Mouchahoir, Katharina S. Yandrofski, Srivalli Telikepalli, Jason King, Paul C. DeRose, Dean C. Ripple, Karen W. Phinney
The NISTmAb Reference Material (RM) 8671 is intended to be the common industry standard monoclonal antibody for pre-competitive research in harmonizing current state-of-the-art technology and designing next generation characterization technologies for

Acid-induced and pH-controlled Reversible Switching of Broad-Spectrum Antibacterial Activity

February 13, 2018
Author(s)
Yin Y. Nelson, Vytautas Reipa, Xiaohong Wang, Kenneth Mineart, Vivek M. Prabhu, Nancy J. Lin, Jirun Sun
Bacterial resistance to antimicrobials is threatening millions of human lives due to indiscriminate overuse and environmental build-up of antibiotics. We present the smart regulation of antibacterial activity in biologically relevant conditions to reduce

Development of Orthogonal NISTmAb Size Heterogeneity Control Methods

February 10, 2018
Author(s)
Abigail Turner, Katharina S. Yandrofski, Srivalli Telikepalli, N. Alan Heckert, James J. Filliben, Dean C. Ripple, John E. Schiel
The NISTmAb is an innovative monoclonal antibody reference material from the National Institute of Standards and Technology; it is a class-representative IgG1κ intended to serve as a pre-competitive platform for harmonization and technology development in

NIST Micronutrients Measurement Quality Assurance Program Winter and Summer 2017 Comparability Studies: Results for Round Robins LXXXI and LXXXII Fat-Soluble Vitamins and Carotenoids in Human Serum

January 10, 2018
Author(s)
Jeanice M. Brown Thomas, David L. Duewer
The National Institute of Standards and Technology coordinates the Micronutrients Measurement Quality Assurance Program (MMQAP) for laboratories that measure fat-soluble vitamins and carotenoids in human serum and plasma. This report describes the design

Modeling, Validation and Verification of Three-Dimensional Cell-Scaffold Contacts from Terabyte- sized Images

December 1, 2017
Author(s)
Peter Bajcsy, Sowon Joy Yoon, Stephen Florczyk, Nathan Hotaling, Mylene H. Simon, Piotr Szczypinski, Nicholas J. Schaub, Carl G. Simon Jr., Mary C. Brady, Ram D. Sriram
Background: Cell-scaffold contact measurements are derived from pairs of co-registered volumetric fluorescent confocal laser scanning microscopy (CLSM) images (z-stacks) of stained cells and spun coat, large microfiber, and medium microfiber scaffolds. Our

Indentation mapping revealed poroelastic, but not viscoelastic,properties spanning native zonal articular cartilage

November 8, 2017
Author(s)
Joseph Wahlquist, Frank W. DelRio, Mark Randolph, Aaron Aziz, Chelsea Heveran, Stephanie Bryant, Corey P. Neu, Virginia L. Ferguson
Osteoarthrosis is a debilitating disease affecting millions, yet engineering materials for cartilage regeneration has proven difficult because of the complex microstructure of this tissue. Articular cartilage, like many biological tissues, produces a time

Buckling Instabilities in Polymer Brush Surfaces via Postpolymerization Modification

October 30, 2017
Author(s)
Wei Guo, Cassandra M. Reese, Li Xiong, Phillip K. Logan, Brittany J. Thompson, Christopher Stafford, Anton Ievlev, Bradley S. Lokitz, Olga S. Ovchinnikova, Derek L. Patton
We report a simple route to engineer ultrathin polymer brush surfaces with wrinkled and creased morphologies using postpolymerization modification (PPM), where the length scale of the buckled features can be tuned using PPM reaction time and sequence. We

Hydrogels with Reversible Mechanics to Probe Dynamic Cell Microenvironments

October 4, 2017
Author(s)
Adrianne Rosales, Sebastain Vega, Frank W. DelRio, Jason Burdick, Kristi S. Anseth
The relationship between ECM mechanics and cell behavior is dynamic, as cells remodel and respond to changes in their local environment. Most in vitro substrates are static and supraphysiologically stiff; thus, platforms with dynamic and reversible

Formation of a crack-free, hybrid skin layer with tunable surface topography and improved gas permeation selectivity on elastomers using gel-liquid infiltration polymerization

September 11, 2017
Author(s)
Justin Gorham, Jason Killgore, Maryam Omidvar, Haiqing Lin, Frank W. DelRio, Lewis M. Cox, Zheng Zhang
Liquid-liquid interfacial polymerization (ll-IP) is conventionally used for manufacturing bulk polymers like nylon, as well as forming barrier layers for reverse osmosis membranes. In this work, we explore the use of gel-liquid infiltration polymerization

3D Cellular Morphotyping of Cell Niches

August 31, 2017
Author(s)
Stephen J. Florczyk, Mylene H. Simon, Derek Juba, Patrick S. Pine, Sumona Sarkar, Desu Chen, Paula J. Baker, Subhadip Bodhak, Antonio Cardone, Mary C. Brady, Peter Bajcsy, Carl G. Simon Jr.
Three-dimensional (3D) cellular morphotyping is introduced for assessing and comparing the niches provided by biomaterial scaffolds. Many scaffold systems have been advanced to provide synthetic cell niches for tissue engineering and drug screening
Displaying 151 - 175 of 1719