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Displaying 101 - 125 of 239

Addiction to MTH1 protein results in intense expression in human breast cancer tissue as measured by liquid chromatography-isotope-dilution tandem mass spectrometry

June 23, 2015
Author(s)
Erdem Coskun, Pawel Jaruga, Ann-Sofie Jemth, Olga Loseva, Leona D. Scanlan, Alessandro Tona, Mark S. Lowenthal, Thomas Helleday, M Miral Dizdar
MTH1 protein sanitizes the nucleotide pool so that modified 2'-deoxynucleoside triphosphates (dNTPs) cannot be used in DNA replication. Cancer cells require MTH1 to avoid incorporation of modified dNTPs resulting in DNA damage mutations and cell death

Bisphenol A leads to oxidative DNA damage and alters the damage response in mouse fibroblasts

February 18, 2015
Author(s)
Pawel Jaruga, Natalie R. Gassman, Erdem Coskun, Donna F. Stefanick, Julie K. Horton, M Miral Dizdar, Samuel H. Wilson
Metabolism of bisphenol A (BPA) generates reactive oxygen species causing DNA strand breaks and damaged DNA bases. Base excision repair (BER) is responsible for removing oxidatively induced DNA base lesions and for repairing single strand breaks (SSBs)

Oxidatively Induced DNA Damage and Its Repair in Cancer

November 25, 2014
Author(s)
M Miral Dizdar
Oxidatively induced DNA damage is caused in living organisms by endogenous and exogenous reactive species. DNA lesions resulting from this type of damage are mutagenic and cytotoxic and, if not repaired, can cause genetic instability that may lead to

Significant disparity in base and sugar damage in DNA by neutron and electron irradiation

July 1, 2014
Author(s)
Pawel Jaruga, Jeffrey S. Nico, Lisa R. Karam, Olga Timofeeva, William Blakely, M Miral Dizdar, D Pang
In this study a comparison of the effects of high-LET neutrons with low-LET electrons on irradiation of aqueous DNA solutions was investigated to characterize for potential neutron signatures on DNA damage induction. Ionizing radiations generate numerous

Inhibition of DNA glycosylases via small molecule purine analogs

December 9, 2013
Author(s)
M Miral Dizdar, Aaron C. Jacobs, Ajit Jadhav, Dorjbal Dorjsuren, David Maloney, Anton Simeonov, Pawel Jaruga, Amanda K. McCullough, R. S. Lloyd
Following the formation of oxidatively-induced DNA damage, several DNA glycosylases are required to initiate repair of the base lesions that are formed. Recently, NEIL1 and other DNA glycosylases, including OGG1 and NTH1 were identified as potential

Identification and Quantification of DNA Repair Protein Apurinic/Apyrimidinic Endonuclease 1 (APE1) in Human Cells by Liquid Chromatography/Isotope-Dilution Tandem Mass Spectrometry

July 29, 2013
Author(s)
Guldal Kirkali, Pawel Jaruga, Prasad T. Reddy, Alessandro Tona, Li Mengxia, David M. Wison III, M Miral Dizdar, Bryant C. Nelson
Unless repaired, DNA damage can drive mutagenesis or cell death. DNA repair proteins may therefore be used as biomarkers in disease detection or therapeutic response estimation. Thus, the accurate measurement of DNA repair protein expression is of

Tools and Approaches for the Assessment of Nanomaterial Induced Oxidative DNA Damage

May 13, 2013
Author(s)
Elijah J. Petersen, Bryce Marquis, Pawel Jaruga, M Miral Dizdar, Bryant C. Nelson
Hyphenated mass spectrometry techniques have been employed as one of the primary analytical tools for investigating the effects of ionizing radiation, chemical/biological carcinogens, and oxygen derived free radicals on the induction and subsequent repair

Oxidatively Induced DNA Damage and Cancer

December 31, 2012
Author(s)
M Miral Dizdar
Endogenous and exogenous sources cause oxidatively induced DNA damage in living organisms by a variety of mechanisms. Resulting DNA lesions are mutagenic and, unless repaired, lead to a variety of mutations and consequently to genetic instability, which a

Identification and Quantification of Human DNA Repair Protein NEIL1 by Liquid Chromatography/Isotope-Dilution Tandem Mass Spectrometry

December 26, 2012
Author(s)
M Miral Dizdar, Pawel Jaruga, Guldal Kirkali, Bryant C. Nelson, Gamze Tuna, Prasad T. Reddy
Accumulated evidence points to DNA repair capacity as an important factor in cancer and other diseases. DNA repair proteins are promising drug targets and are emerging as prognostic and therapeutic biomarkers. Thus, the knowledge of the overexpression or