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Search Publications by: Joy Dunkers (Fed)

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Displaying 1 - 25 of 197

mDTEB, a new fluorescent label for carbohydrate nano-material in vivo studies

May 27, 2023
Author(s)
Jeremiah Woodcock, Douglas M. Fox, Ilabahen A. Patel, Joy Dunkers, Stephan J. Stranick, Jeffrey W. Gilman
Typical studies of gastral toxicity are conducted using radio labeling. This tends to be quite expensive and difficult owing to the required protocols for working with these materials and the expense of the chemical reagents. A possible alternative is

Three-dimensional, label-free cell viability measurements in tissue engineering scaffolds using optical coherence tomography

March 14, 2023
Author(s)
Greta Babakhanova, Anant Agrawal, Deepika Arora, Allison Horenberg, Jagat Budhathoki, Joy Dunkers, Joe Chalfoun, Peter Bajcsy, Carl Simon Jr.
In the field of tissue engineering, 3D scaffolds and cells are often combined to yield constructs that are used as therapeutics to repair or restore tissue function in patients. Viable cells are required to achieve the intended mechanism of action for the

Report from the NIST Workshop: Launch of the Rapid Microbial Testing Methods Consortium

September 27, 2022
Author(s)
Nancy Lin, Scott Jackson, Stephanie Servetas, Kirsten Parratt, Joy Dunkers, Tara Eskandari, Sheng Lin-Gibson
On September 17, 2020, NIST hosted a virtual workshop to launch the Rapid Microbial Testing Methods (RMTM) Consortium. The RMTM Consortium aims to address the need for measurements and standards to increase confidence in the use of rapid testing for

Micromechanical Compatibility Between Cells and Scaffolds Directs Phenotypic Transition of Stem Cells

January 28, 2022
Author(s)
Yang Song, Jiaoyue Long, Jeremiah Woodcock, Joy Dunkers, Hung Chun Lin, Douglas M. Fox, Xiaoling Liao, Yonggang Lv, Li Yang, Martin Chiang
This study experimentally substantiates the micromechanical compatibility between cell and substrate is essential for cells to achieve energetically favorable mechanotransduction that directs phenotypic transitions. The argument for this compatibility is

Towards Absolute Viability Measurements for Bacteria

September 12, 2021
Author(s)
Joy Dunkers, Hariharan K. Iyer, Brynna H. Jones, Charles Camp, Stephan J. Stranick, Nancy Lin
Quantifying viable, vegetative bacteria is a critical measurand in healthcare diagnostics, food safety, and antimicrobial development. Viability determination has traditionally relied on such techniques as plate counting, colorimetric or fluorescent

Methods for Characterization of Bioactivity Using Confocal Microscopy

December 1, 2020
Author(s)
Jirun Sun, Nancy Lin, Joy Dunkers, Sheng Lin-Gibson
One common tissue engineering approach for regenerating or replacing damaged tissues involves a porous polymeric scaffold. The scaffolds serve as the mechanical framework for cell attachment and growth, and generate an environment with features that span

Key Considerations for Microbial Viability Measurements

January 14, 2020
Author(s)
Joy Dunkers, Sandra M. Da Silva, Stephanie Servetas, James J. Filliben, Guilherme L. Pinheiro, Nancy Lin
Making reliable measurements of antimicrobial killing efficacy requires careful consideration of the sources of biological variability, measurement bias and error throughout the entire workflow. For ultraviolet-C (UV-C) disinfection, killing efficacy is

Structural Insights into DNA-Stabilized Silver Clusters

May 10, 2019
Author(s)
Danielle Schultz, Robert G. Brinson, Fahriye N. Sari, Jeffrey Fagan, Christina Bergonzo, Nancy Lin, Joy Dunkers
The structure and dynamics of Ag complexes derived from single stranded DNA (ssDNA) is less understood than their double stranded (dsDNA) counterparts despite their great promise as fluorescent biological probes and sensors. In this work, we seek new

Roles of Nanofiber Scaffold Structure and Chemistry in Directing Human Bone Marrow Stromal Cell Response

August 22, 2016
Author(s)
Sumona Sarkar, Bryan A. Baker, Desu Chen, Patrick S. Pine, Jennifer H. McDaniel, Marc L. Salit, Wolfgang Losert, Carl G. Simon Jr., Joy P. Dunkers
Nanofiber technology has emerged as a promising tool to recapitulate the native extracellular matrix structure; however the properties of nanofibers governing cell-material interactions are still largely undetermined. In this study we have systematically

Machine Learning Strategy to Determine Cell Shape Phenotypes Associated with Micro-Environmental Cues

June 25, 2016
Author(s)
Desu Chen, Sumona Sarkar, Julian Candia, Carl G. Simon Jr., Wolfgang Losert, Joy P. Dunkers, Stephen J. Florczyk, Subhadip Bodhak, Meghan Driscoll
Cell morphology has been identified as a potential indicator of stem cell response and function in biomaterial environments. However, determination of cell shape phenotype in biomaterials is complicated by heterogeneous cell populations, heterogeneous

The Testing Program at NIST on Fibers Used in Soft Body Armor Applications

March 21, 2015
Author(s)
Walter G. McDonough, Amanda L. Forster, Jae Hyun Kim, Nathanael A. Heckert, Joy P. Dunkers, Scott A. Wight, Gale A. Holmes
The goal of this paper and presentation is to give an update of the research effort to date being conducted at the National Institute of Standards and Technology (NIST) on polymeric fibers used in soft body armor with a special emphasis on new fibers under