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Search Publications by: Bryant C. Nelson (Fed)

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Displaying 26 - 50 of 158

Approaches for the Quantitative Analysis of Oxidation State in Cerium Oxide Nanomaterials

September 21, 2018
Author(s)
Christopher M. Sims, Russell A. Maier, Aaron C. Johnston-Peck, Justin M. Gorham, Vincent A. Hackley, Bryant C. Nelson
Cerium oxide nanomaterials (nanoceria, CNMs) are receiving increased attention from the research community due to their unique chemical properties, most prominent of which is their ability to alternate between the Ce3+ and Ce4+ oxidation states. While many

Agglomeration of Escherichia coli with positively charged nanoparticles can lead to artifacts in a standard Caenorhabditis elegans toxicity assay

April 19, 2018
Author(s)
Shannon Hanna, Antonio Montoro Bustos, Alexander W. Peterson, Vytas Reipa, Leona D. Scanlan, Sanem Hosbas Coskun, Tae Joon Cho, Monique Johnson, Vincent A. Hackley, Bryant C. Nelson, Michael R. Winchester, John T. Elliott, Elijah Petersen
The increased use and incorporation of engineered nanoparticles (ENPs) in consumer products requires a robust assessment of their potential environmental implications. However, a lack of standardized methods for nanotoxicity testing has yielded results

Counting Caenorhabditis elegans: Protocol Optimization and Applications for Population Growth and Toxicity Studies in Liquid Medium

January 17, 2018
Author(s)
Steven Lund, Sanem Hosbas Coskun, Monique Johnson, Christopher Sims, Elijah Petersen, John T. Elliott, Bryant C. Nelson, Leona D. Scanlan, Shannon K. Hanna, Karina Brignoni, Patricia Lapasett
The nematode Caenorhabditis elegans is used extensively in molecular, toxicological and genetics research. However, standardized methods for counting nematodes in liquid culture do not exist despite the wide use of nematodes and need for accurate

Controlled Potential Electrooxidation of Genomic DNA

January 11, 2018
Author(s)
Vytautas Reipa, Donald H. Atha, Sanem Hosbas Coskun, Christopher M. Sims, Bryant C. Nelson
Exposure of mammalian cells to oxidative stress can result in DNA damage that adversely affects many cell processes. We used bulk electrolysis in an electrochemical system and gas chromatographic mass spectrometric analysis (GC/MS/MS) to control and

Sucrose density gradient centrifugation for efficient separation of engineered nanoparticles from a model organism, Caenorhabditis elegans

October 11, 2017
Author(s)
Monique E. Johnson, Antonio R. Montoro Bustos, Elijah J. Petersen, Shannon K. Hanna, Karen E. Murphy, Lee L. Yu, Bryant C. Nelson, Michael R. Winchester
This protocol describes a strategy for separating Caenorhabditis elegans (C. elegans) from engineered nanomaterials, a critical step for accurate quantification in uptake studies. Conventional rinsing procedures, typically comprised of water or buffer

Redox-active Nanomaterials for Nanomedicine Applications

October 6, 2017
Author(s)
Christopher Sims, Shannon Hanna, Daniel A. Heller, Christopher Horoszko, Monique Johnson, Antonio Montoro Bustos, Vytas Reipa, Kathryn Riley, Bryant C. Nelson
Nanomedicine utilizes the remarkable properties of nanomaterials for the diagnosis, treatment, and prevention of disease. Many of these nanomaterials have been shown to have robust antioxidative properties, potentially functioning as strong scavengers of

Multiple method analysis of TiO2 nanoparticles uptake, accumulation and effects in rice (Oryza sativa L.) plants

August 4, 2017
Author(s)
Yinqging Deng, Elijah Petersen, Katie Challis, Savelas A. Rabb, Richard D. Holbrook, James Ranville, Bryant C. Nelson, Baoshan Xing
Understanding the translocation of nanoparticles (NPs) into plants is challenging because quantitative and qualitative methods are still being developed and the comparability of results among different methods is unclear. In this study, the uptake of NPs

Exposure to Engineered Nanomaterials: Impact on DNA Repair Pathways

July 13, 2017
Author(s)
Neenu Singh, Bryant C. Nelson, Leona D. Scanlan, Erdem Coskun, Pawel Jaruga, Shareen Doak
Some engineered nanomaterials (ENMs) may have the potential to cause damage to the genetic material in living systems. The mechanistic machinery functioning at the cellular/molecular level, in the form of DNA repair processes, has evolved to help

Quantitative Analysis of Oxidation State in Cerium Oxide Nanomaterials

May 14, 2017
Author(s)
Christopher Sims, Russell Maier, Aaron Johnston-Peck, Justin Gorham, Vincent A. Hackley, Bryant C. Nelson
Cerium oxide nanoparticles (nanoceria) are receiving increased attention from the research community due to the large number and wide range of their current and potential applications. The attractiveness of nanoceria for these various applications is

Biophysical Characterization of Functionalized Titania Nanoparticles and Their Application in Dental Adhesives

February 2, 2017
Author(s)
Jirun Sun, Elijah Petersen, Stephanie S. Watson, Christopher Sims, Alexander Kassman, Stanislav Frukhtbeyn, Drago Skrtic, Meryem T. Ok, Deborah Jacobs, Qiang Ye, Bryant C. Nelson
It is demonstrated that carboxylic acid-functionalized titanium dioxide (TiO2) NPs produce significantly higher levels of reactive oxygen species (ROS) after visible light irradiation (400-800 nm, 1600 mW/cm2) in comparison to nonfunctionalized TiO2 NPs

Separation, Sizing, and Quantitation of Engineered Nanoparticles in an Organism Model Using Inductively Coupled Plasma Mass Spectrometry and Image Analysis

December 16, 2016
Author(s)
Monique E. Johnson, Shannon Hanna, Antonio R. Montoro Bustos, Christopher M. Sims, Lindsay C. Elliott, Babak Nikoobakht, John T. Elliott, Richard D. Holbrook, Keana C. Scott, Karen E. Murphy, Elijah J. Petersen, Lee L. Yu, Bryant C. Nelson, Akshay Lingayat, Adrian C. Johnston
For environmental studies assessing uptake of orally ingested engineered nanoparticles (ENPs), a key step in ensuring accurate quantification of ingested ENPs is efficient separation of the organism from ENPs that are either nonspecifically adsorbed to the

Defense Mechanisms and Nutrient Displacement in Arabidopsis thaliana upon Exposure to CeO2 and In2O3 Nanoparticles

September 1, 2016
Author(s)
Bryant C. Nelson, Sanem Hosbas Coskun, Chuanxin Ma, Hong Li, Huiyuan Guo, Craig Musante, Jason C. White, Baoshan Xing, Om P. Dhankher
Metal-based nanoparticles (NPs) can cause toxicity to terrestrial plants, however there is little understanding of plant defense mechanisms that may counteract nanotoxicity. In the present study, we investigated the defense mechanisms of Arabidopsis

Emerging Metrology for High Throughput Nanomaterial Genotoxicology

August 26, 2016
Author(s)
Bryant C. Nelson, Christa W. Wright, Yuko Ibuki, Maria Moreno-Villanueva, Hanna L. Karlsson, Giel Hendriks, Christopher M. Sims, Neenu Singh, Shareen H. Doak
The rapid development of the engineered nanomaterial (ENM) manufacturing industry has accelerated the incorporation of ENMs into a wide variety of consumer products across the globe. Unintentionally or not, some of these ENMs may be introduced into the