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Search Publications by: Bryant C. Nelson (Fed)

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Displaying 51 - 75 of 158

Design, sensitivity analysis, and testing of a Caenorhabditis elegans nanoecotoxicity assay

August 11, 2016
Author(s)
Shannon Hanna, Gregory A. Cooksey, Bryant C. Nelson, John T. Elliott, Elijah J. Petersen
Increasing production and usage of engineered nanomaterials (ENMs) has generated widespread interest in measuring their environmental and human health effects. However, the lack of standardized methods for these measurements has often led to contradictory

Measurement of DNA repair protein apurinic/apyrimidinic endonuclease 1 (APE1) in human tissues by liquid chromatography/tandem mass spectrometry with isotope dilution

June 5, 2016
Author(s)
Pawel Jaruga, Guldal Kirkali, Prasad T. Reddy, Alessandro Tona, Bryant C. Nelson, Li Mengxia, David M. Wilson III, Erdem Coskun, M Miral Dizdar
Introduction DNA repair proteins may be used as biomarkers in disease etiology and therapy. Thus, the accurate determination of DNA repair protein expression and genotype in human tissues is of fundamental importance. Apurinic/apyrimidinic endonuclease 1

Antioxidant Cerium Oxide Nanoparticles in Biology and Medicine

May 17, 2016
Author(s)
Bryant C. Nelson, Monique E. Johnson, Marlon L. Walker, Kathryn R. Riley, Christopher M. Sims
Previously, catalytic cerium oxide nanoparticles (CNPs, nanoceria, CeO2-x NPs) have been widely utilized for chemical mechanical planarization in the semiconductor industry and for reducing harmful emissions and improving fuel combustion efficiency in the

GC-MS/MS Measurement of Nanomaterial Induced Genotoxicity in Isolated DNA

November 24, 2015
Author(s)
Bryant C. Nelson, Elijah J. Petersen, Pawel Jaruga, M Miral Dizdar
Making accurate measurements of the environmental fate and environmental and biological effects of engineered nanomaterials (ENMs) is critical for reliable risk assessment of these materials. ENM induced oxidative stress and/or direct binding of ENMs to

GC/MS Measurement of Nanomaterial Induced Genotoxicity in Isolated DNA

November 24, 2015
Author(s)
Bryant C. Nelson, Elijah J. Petersen, Pawel Jaruga, M Miral Dizdar
Making accurate measurements of the environmental fate and environmental and biological effects of engineered nanomaterials (ENMs) is critical for reliable risk assessment of these materials. ENM induced oxidative stress and/or direct binding of ENMs to

LC-MS/MS Measurement of Nanomaterial Induced Genotoxicity in Isolated DNA

November 24, 2015
Author(s)
Bryant C. Nelson, Elijah J. Petersen, Pawel Jaruga, M Miral Dizdar
Making accurate measurements of the environmental fate and environmental and biological effects of engineered nanomaterials (ENMs) is critical for reliable risk assessment of these materials. However, the unique behaviors of ENMs may cause artifacts in

Production, Purification and Characterization of 15N-Labeled DNA Repair Proteins as Internal Standards for Mass Spectrometric Measurements

July 26, 2015
Author(s)
Prasad T. Reddy, Pawel Jaruga, Bryant C. Nelson, Mark Lowenthal, Ann-Sofie Jemth, Olga Loseva, Erdem Coskun, Thomas Helleday, Miral M. Dizdar
Oxidatively induced DNA damage is caused in living organisms by a variety of damaging agents, resulting in the formation of a multiplicity of lesions, which are mutagenic and cytotoxic. Unless repaired by DNA repair mechanisms before DNA replication, DNA

Assessment of Crude Oil and a Dispersant in a Simulated Spartina alterniflora Salt Marsh Ecosystem

December 1, 2014
Author(s)
P Key, K Chung, C Cooksey, DeLorenzo M, M Fulton, D Greenfield, T Greig, J Hylund, Bryant C. Nelson, Varun Patel, P Pennington, Elijah Petersen, E Wirth
NOAA's Environmental Sensitivity Index (ESI) lists saltmarshes along the Atlantic and Gulf Coasts as the most vulnerable habitat to oil spills. As a result of the Deepwater Horizon offshore drilling rig accident, more that 200 million gallons of crude oil

The DNA Damaging Potential of Photoactivated P25 Titanium Dioxide Nanoparticles

September 30, 2014
Author(s)
Elijah Petersen, Vytas Reipa, Stephanie S. Watson, Deborah Jacobs, Savelas A. Rabb, Bryant C. Nelson
Titanium dioxide nanoparticles (TiO2 NPs) are found in numerous commercial and personal care products. Thus, it is necessary to understand and characterize their potential environmental health and safety risks. It is well known that photoactivated TiO2 NPs

Using Single Particle ICP-MS as a Tool for Understanding Metallic Nanoparticle Transformation during Nanotoxicity Assays

July 1, 2014
Author(s)
Monique E. Johnson, Shannon Hanna, Antonio R. Montoro Bustos, Bryant C. Nelson, Elijah J. Petersen, Lee L. Yu
The advent of engineered nanoparticles (ENPs) and their increased use has remarkably improved the performance of basic materials and consumer products, but has also increased the potential for ENP release into the environment. Technical procedures, more