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Search Publications by: Bryant C. Nelson (Fed)

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Displaying 76 - 100 of 158

Development of a Standard Reference Material for Metabolomics Research

November 4, 2013
Author(s)
Karen W. Phinney, Guillaume Ballihaut, Mary Bedner, Johanna Camara, Steven J. Christopher, William C. Davis, Nathan G. Dodder, Brian E. Lang, Stephen E. Long, Mark S. Lowenthal, Elizabeth A. McGaw, Karen E. Murphy, Bryant C. Nelson, Jocelyn L. Prendergast, Jessica L. Reiner, Catherine A. Rimmer, Lane C. Sander, Michele M. Schantz, Katherine E. Sharpless, Lorna T. Sniegoski, Susan S. Tai, Jeanice M. Brown Thomas, Thomas W. Vetter, Michael J. Welch, Stephen A. Wise, Laura J. Wood, William F. Guthrie, Robert C. Hagwood, Stefan D. Leigh, James H. Yen, Nien F. Zhang, Madhu Chaurhary-Webb, Huiping Chen, Bridgette Haynes, Donna J. LaVoie, Leslie F. McCoy, Shahzad S. Momin, Neelima Paladugula, Elizabeth C. Pendergrast, Christine M. Pfeiffer, Carissa D. Powers, Zia Fazili-Qari, Daniel Rabinowitz, Michael E. Rybak, Rosemary L. Schleicher, Mary Xu, Mindy Zhang, Arthur L. Castle, Brandi S. Benford, Gauthier Eppe

Functionalization-Dependent Induction of Cellular Survival Pathways by CdSe Quantum Dots in Primary Normal Human Bronchial Epithelial Cells

September 5, 2013
Author(s)
Amber Nagy, Jennifer A. Hollingsworth, Bin Hu, Andrea Steinbruck, Peter C. Stark, Cristina Rios Valdez, Momchilo Vuyisich, Michael H. Stewart, Donald H. Atha, Bryant C. Nelson, Rashi Iyer
Quantum dots (QDs) are semiconductor nanocrystals exhibiting unique optical properties which can be exploited for many practical applications ranging from photovoltaics to biomedical imaging and drug delivery. They are increasingly manufactured in large

Identification and Quantification of DNA Repair Protein Apurinic/Apyrimidinic Endonuclease 1 (APE1) in Human Cells by Liquid Chromatography/Isotope-Dilution Tandem Mass Spectrometry

July 29, 2013
Author(s)
Guldal Kirkali, Pawel Jaruga, Prasad T. Reddy, Alessandro Tona, Li Mengxia, David M. Wison III, M Miral Dizdar, Bryant C. Nelson
Unless repaired, DNA damage can drive mutagenesis or cell death. DNA repair proteins may therefore be used as biomarkers in disease detection or therapeutic response estimation. Thus, the accurate measurement of DNA repair protein expression is of

Tools and Approaches for the Assessment of Nanomaterial Induced Oxidative DNA Damage

May 13, 2013
Author(s)
Elijah J. Petersen, Bryce Marquis, Pawel Jaruga, M Miral Dizdar, Bryant C. Nelson
Hyphenated mass spectrometry techniques have been employed as one of the primary analytical tools for investigating the effects of ionizing radiation, chemical/biological carcinogens, and oxygen derived free radicals on the induction and subsequent repair

Nanosilver suppresses growth and induces oxidative damage to DNA in Caenorhabditis elegans

May 2, 2013
Author(s)
Bryant C. Nelson, Bryce J. Marquis, Piper R. Hunt, Katherine M. Tyner, Sean Conklin, Nicholas Olejnik, Robert L. Sprando
The utility of C. elegans as an alternative model to assess nanomaterial toxicity was evaluated using 10 nm silver particles (10nmAg). Endpoints of nanomaterial uptake and localization, larval growth, morphology, and DNA damage were assessed. Orally

Active Transcriptomic and Proteomic Reprogramming in the C. elegans Nucleotide Excision Repair Mutant xpa-1

April 9, 2013
Author(s)
Katarzyna Arczewska, Gisele Tomazella, Jessica Lindvall, Henok Kassahun, Silvia Maglioni, Alessandro Torgovnick, Johan Henriksson, Olli Matilainen, Bryce J. Marquis, Bryant Nelson, Eshrat Babaie, Carina Holmberg, Thomas Burglin, Natascia Ventura, Bernd Thiede, Hilde Nilsen
Transcription-blocking oxidative DNA damage is believed to contribute to aging and to underlie activation of oxidative stress-responses and down-regulation of insulin-like signaling (ILS) in Nucleotide Excision Repair (NER) deficient mice. Here, we present

NIST Gold Nanoparticle Reference Materials Do Not Induce Oxidative DNA Damage

February 1, 2013
Author(s)
Bryant C. Nelson, Donald H. Atha, John T. Elliott, Bryce J. Marquis, Elijah J. Petersen, Danielle Cleveland, Stephanie S. Watson, I-Hsiang Tseng, Andrew Dillon, Melissa Theodore, Joany Jackman
Well-characterized, nanoparticle reference materials are urgently needed for nanomaterial toxicity studies. The National Institute of Standards and Technology has developed three gold nanoparticle (AuNP) reference materials (10 nm, 30 nm, 60 nm) to address

Identification and Quantification of Human DNA Repair Protein NEIL1 by Liquid Chromatography/Isotope-Dilution Tandem Mass Spectrometry

December 26, 2012
Author(s)
M Miral Dizdar, Pawel Jaruga, Guldal Kirkali, Bryant C. Nelson, Gamze Tuna, Prasad T. Reddy
Accumulated evidence points to DNA repair capacity as an important factor in cancer and other diseases. DNA repair proteins are promising drug targets and are emerging as prognostic and therapeutic biomarkers. Thus, the knowledge of the overexpression or

Tools and Approaches for the Assessment of Nanomaterial Induced Oxidative DNA Damage

June 20, 2012
Author(s)
Elijah J. Petersen, Bryce J. Marquis, Pawel Jaruga, M Miral Dizdar, Bryant C. Nelson
Hyphenated mass spectrometry techniques have been employed as one of the primary analytical tools for investigating the effects of ionizing radiation, chemical/biological carcinogens, and oxygen derived free radicals on the induction and subsequent repair

Identification and quantification of DNA repair proteins by liquid chromatography/isotope-dilution tandem mass spectrometry using 15N-labeled whole proteins as internal standards

May 30, 2012
Author(s)
M Miral Dizdar, Prasad T. Reddy, Guldal Kirkali, Gamze Tuna, Bryant C. Nelson, Pawel Jaruga
Oxidatively induced DNA damage is implicated in disease, unless it is repaired by DNA repair. DNA repair proteins may be used as early detection and therapeutic biomarkers in cancer and other diseases. For this purpose, the measurement of the expression