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Search Publications by: Carl G. Simon, Jr., Ph.D. (Fed)

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Displaying 76 - 100 of 265

Evaluation of the effect of donor variability on stem cell response to biomaterials

April 19, 2014
Author(s)
Stephen J. Florczyk, Bryan A. Baker, Sumona Sarkar, Jennifer H. McDaniel, Patrick S. Pine, Marc L. Salit, Carl G. Simon Jr.
Previous research from our group indicated that nanofiber scaffolds promoted osteogenic differentiation of human bone marrow stromal cells (hBMSC) and similar gene expression to osteogenic supplement (OS) induced osteogenic differentiation [1]. Biological

Machine Learning Analysis for Identification of Cell Shape Metrics Associated with Stem Cell Differentiation in Nanofiber Scaffolds

April 19, 2014
Author(s)
Desu Chen, Sumona Sarkar, Stephen J. Florczyk, Subhadip Bodhak, Carl G. Simon Jr., Joy P. Dunkers, Julian Candia, Wolfgang Losert
Cell shape has been demonstrated to be closely related to cell function and may be an important predictor of cell fate. Many metrics are available to describe cell shape, however the relationship of these metrics to cell fate are not well understood

Measuring Organelle Shape in 3D in Stem Cells Cultured on Nanofiber Scaffolds

April 19, 2014
Author(s)
Carl G. Simon Jr., Peter Bajcsy, Wojtek J. Tutak, Jyotsnendu J. Giri
Previous work has demonstrated that culture of osteoprogenitor cells on nanofiber scaffolds can potentiate osteogenic differentiation [1-4]. Culture of cells in nanofiber scaffolds causes changes to cell morphology, suggesting that morphological changes

Measuring Stem Cell Dimensionality in Tissue Scaffolds

April 1, 2014
Author(s)
Carl G. Simon Jr., Sapun Parekh, Christopher K. Tison, Girish Kumar, Tanya M. Farooque, Charles H. Camp
Many 3D scaffold systems have evolved for tissue engineering, drug screening and in vitro tissue models. However, it is not clear which scaffolds provide a 3D cell niche and there is no clear way to measure cell niche dimensionality. Advances in 3D niche

Airbrushed Nanofiber Scaffolds Support Bone Marrow Stromal Cell Differentiation

November 1, 2013
Author(s)
Carl G. Simon Jr., Wojtek J. Tutak, Sumona Sarkar, Tanya M. Farooque, Jyotsnendu J. Giri, Dongbo Wang, Sheng Lin-Gibson, Joachim Kohn, Durgadas Bolikal
Nanofiber scaffolds are effective for tissue engineering since they emulate the fibrous nanostructure of native extracellular matrix (ECM). Although electrospinning has been the most common approach for fabricating nanofiber scaffolds, airbrushing

Parallel Geometric Classification of Stem Cells by Their 3D Morphology

July 1, 2013
Author(s)
Derek Juba, Antonio Cardone, Cheuk Y. Ip, Carl Simon Jr., Christopher K. Tison, Girish Kumar, Mary C. Brady
Autologous stem cells show great promise for tissue engineering as they can regenerate diseased or damaged tissue, without requiring an organ donor or causing immune rejection. A primary goal of regenerative medicine is to identify methods for controlling

Effect of Surface Chemistry on Stem Cell Response in 2-D vs. 3-D Cell Culture Niches

April 19, 2013
Author(s)
Sumona Sarkar, Carl G. Simon Jr., Roberta I. Lock, Joy P. Dunkers
To develop tissue engineered devices for regenerative medicine strategies, key scaffold properties for directing stem cell response must be identified. As focus shifts from 2-D to 3-D culture systems in an attempt to better recapitulate the natural

Gradient Nanofiber Scaffold Libraries for Screening Cell Response to Poly(e-caprolactone)-Calcium Phosphate Composites

March 1, 2013
Author(s)
Carl G. Simon Jr., Limin Sun, Laurence C. Chow, William Miles, Christopher K. Tison, Kaushik Chatterjee, Marian F. Young, Vinoy Thomas, Murugan Ramalingam
A 2-spinnerette approach has been developed for fabricating nanofiber scaffold gradients for use as 1) scaffold libraries for screening the effect of nanofiber properties on cell response and 2) templates for generating graded tissue interfaces. Although

Optimization of Imaging Polymer Based Scaffolds Using X-Ray Microcomputed Tomography

May 15, 2012
Author(s)
David E. Morris, Melissa L. Mather, Carl Simon Jr., John A. Crowe
The performance of polymer based scaffolds used in regenerative medicine is linked to their structural properties and as such strategies for structural characterization of scaffolds have been developed. X-ray microscopic computed tomography (X-ray micro CT

Gas-Foamed Scaffold Gradients for Combinatorial Screening in 3D

May 1, 2012
Author(s)
Carl G. Simon Jr., Kaushik Chatterjee, Alison M. Kraigsley, Joachim Kohn, Durgadas Bolikal
Current methods for screening cell-material interactions typically utilize two-dimensional (2D) culture format where cells are cultured on flat surfaces. However, there is a need for combinatorial and high-throughput screening methods to systematically