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Search Publications by: Carl G. Simon, Jr., Ph.D. (Fed)

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Displaying 126 - 150 of 265

NIST Reference Material Scaffolds Characterized for Cell Response

April 24, 2011
Author(s)
Carl G. Simon Jr., Jeff M. Coles
Reference scaffolds characterized for cell response are being developed for use as a standard for biological characterization of new scaffolds. The need for reference scaffolds to serve as a calibration standard between labs has been identified as critical

Development of Probe Free Mapping of Cell Viability in Hydrogels

April 16, 2011
Author(s)
Joy P. Dunkers, Kaushik Chatterjee, Carl G. Simon Jr.
Diffusion of oxygen in cell/scaffold construct interior is of critical importance to cell viability in constructs of clinically relevant sizes. It has been shown that depletion of oxygen within the scaffold leads to a decrease in cell density and viability

Modulus-Driven Differentiation of Marrow Stromal Cells in 3D Is Independent of Cytoskeletal Integrity

April 11, 2011
Author(s)
Carl G. Simon Jr., Kaushik Chatterjee, Sapun Parekh, Sheng Lin-Gibson, Nicole M. Moore, Marcus T. Cicerone, Marian F. Young
Cell functions such as proliferation, migration, and differentiation are key physiological processes that are influenced by the physiochemical extracellular environment. We report on the effect of three-dimensional (3D) scaffold modulus on human bone

3D Polymer Scaffold Arrays

December 5, 2010
Author(s)
Carl G. Simon Jr., Yanyin Yang, Shauna M. Dorsey, Murugan Ramalingam, Kaushik Chatterjee
We have developed a combinatorial platform for screening the effect polymer scaffold properties and composition on cell response. Traditional research involves preparing samples one at a time for characterization and testing. Combinatorial and high

Effect of 3D Hydrogel Scaffold Stiffness on Human Bone Marrow Stromal Cell Differentiation

November 1, 2010
Author(s)
Carl G. Simon Jr., Sapun Parekh, Marcus T. Cicerone, Sheng Lin-Gibson, Kaushik Chatterjee, Marian F. Young
There is growing recognition cells can sense and respond to the mechanical properties of tissue scaffolds and that these interactions are critical in optimizing scaffold design [1-4]. Previous studies in planar 2D culture format have shown that human bone

Effect of 3D Hydogel Scaffold Modulus and Topology on Human Bone Marrow Stromal Cell Fate

September 1, 2010
Author(s)
Kaushik Chatterjee, Sheng Lin-Gibson, Sapun Parekh, Nicole M. Moore, Marcus T. Cicerone, marian F. young, Carl Simon Jr.
There is growing recognition that cells can sense and respond to the physical cues from their environment, such as stiffness, mechanical loading and topology. Physical properties of the matrix can direct cellular response and are critical in the design of

Gradient Nanofiber Scaffold Libraries for Rapid Screening of Cell-Material Interactions

December 1, 2009
Author(s)
Carl G. Simon Jr., Murugan Ramalingam, Marian F. Young, Vinoy Thomas
Scaffolds play a key role in tissue engineering wherein they provide structural support for cells to adhere, grow and guide them to synthesize tissue. Scaffolds made of multiple biomaterials are typically required to mimic the three-dimensional (3D)

NIST Reference Material Scaffolds for Tissue Engineering

December 1, 2009
Author(s)
Carl G. Simon Jr.
The National Institute of Standards and Technology (NIST) has deployed Reference Material (RM) scaffolds for tissue engineering: a series of well-characterized 3D tissue scaffolds with differing porosities (RM 8395, RM 8396 and RM 8397) (Fig. 1). Customers