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Search Publications by: Carl G. Simon, Jr., Ph.D. (Fed)

Displaying 151 - 175 of 265

NIST Reference Material Scaffolds for Tissue Engineering

December 1, 2009

Author(s)

Carl G. Simon Jr.

The National Institute of Standards and Technology (NIST) has deployed Reference Material (RM) scaffolds for tissue engineering: a series of well-characterized 3D tissue scaffolds with differing porosities (RM 8395, RM 8396 and RM 8397) (Fig. 1). Customers

Preface to Special Issue: Combinatorial and High-Throughput Screening of Cell Response to Biomaterials

December 1, 2009

Author(s)

Carl G. Simon Jr.

Despite significant investment in tissue engineering research, few profitable products have come to market. Hence, there is a need to accelerate tissue engineering research. One approach to accelerating research is combinatorial and high-throughput (CHT)

PEG-HYDROGELS: SYNTHESIS, CHARACTERIZATION, AND CELL ENCAPSULATION

September 15, 2009

Author(s)

Sheng Lin-Gibson, Kaushik Chatterjee, James A. Cooper, William E. Wallace, Matthew Becker, Carl G. Simon Jr., Ferenc Horkay

A simple reaction to prepare controlled molecular mass (MM) poly(ethylene glycol) dimethacrylates (PEGDMs) of high purity and low polydispersity is outlined. PEGDMs were photo-polymerized to form hydrogels with and without bioactive moieties. The structure

Cell Interactions with Biomaterials Gradients and Arrays

August 4, 2009

Author(s)

Yanyin Yang, Vinoy Thomas, Abby W. Morgan, Shauna M. Dorsey, Carl Simon Jr.

Gradients and arrays have become very useful to the fields of tissue engineering and biomaterials. Both gradients and arrays make efficient platforms for screening cell response to biomaterials. Graded biomaterials also have functional applications and

Combinatorial Screening of Hydrogel Properties for 3-D Cell Culture: Effect of Stiffness on Encapsulated Osteoblasts

July 15, 2009

Author(s)

Carl G. Simon Jr., Kaushik Chatterjee, Sheng Lin-Gibson, William E. Wallace, Marian F. Young

A combinatorial method to rapidly screen cell-material interactions in three-dimensional (3-D) culture format was developed for accelerating tissue engineering research. Hydrogels of poly(ethylene glycol) dimethacrylate (PEGDM) with gradients in

Measuring Cell Adhesion and Proliferation in Polymer Scaffolds by X-Ray Microcomputed Tomography

April 30, 2009

Author(s)

Shauna M. Dorsey, Sheng Lin-Gibson, Carl Simon Jr.

Statement of Purpose: We have investigated the ability of X-ray microcomputed tomography (CT) to make three-dimensional (3D) measurements of cell adhesion and proliferation in polymeric tissue engineering scaffolds [1]. Standard methods for measuring cell

Combinatorial Method for Screening the Effect of Nanofiber Scaffold Composition on Cell Response

April 25, 2009

Author(s)

Murugan Ramalingam, Marian F. Young, Vinoy Thomas, Carl Simon Jr.

Statement of Purpose: We are developing combinatorial methods for screening cell-material interactions. Although previous approaches for rapid screening have used material libraries in the form of two-dimensional surfaces or films (2D), biomaterials are

Rapid Screening of Hydrogel Properties for 3D Tissue Culture: Effect of Modulus on Encapsulated Osteoblasts

April 25, 2009

Author(s)

Kaushik Chatterjee, Sheng Lin-Gibson, Marian F. Young, William E. Wallace, Carl Simon Jr.

Statement of Purpose: With few successful products in the market despite large investments in tissue engineering research, there is a need to accelerate tissue engineering research. Towards this objective, developing high-throughput platforms to rapidly

Measuring Cell Adhesion and Proliferation in Polymer Scaffolds by X-Ray Microcomputed Tomography

February 23, 2009

Author(s)

Shauna M. Dorsey, Sheng Lin-Gibson, Carl Simon Jr.

We have explored a new X-ray microcomputed tomography method (CT) for assessing cell adhesion and proliferation in polymer scaffolds. Standard methods for examining cells in scaffolds include fluorescence microscopy and soluble assays for cell components

Beta-Sheet Formation and RGD-Presentation Effects on Osteoblast Differentiation

November 15, 2008

Author(s)

Carl G. Simon Jr., Matthew Becker, Sheng Lin-Gibson, Kristen E. Roskov, David L. Kaplan, Abby W. Morgan

This report highlights our recent investigation into -sheet formation and RGD epitope presentation on the surface of blended silk films.1 Surface characterization of biomaterials for tissue engineering applications is of great importance to understand how

Gradient Nanofiber Scaffold Libraries for Tissue Regeneration by Electrospinning

October 15, 2008

Author(s)

Carl G. Simon Jr., Murugan Ramalingam, Marian F. Young, Vinoy Thomas

Functional tissue engineering is a rapidly emerging biomedical field that holds great potential for healthcare in addressing the gap between need and availability of donor tissues and organs. The dogma in the field of tissue engineering is to harvest a

Injectable and strong nano-apatite scaffolds for cell/growth factor delivery and bone regeneration

July 20, 2008

Author(s)

Carl G. Simon Jr., Hockin D. Xu, Michael Weir

Objectives. Seven million people suffer bone fractures each year in the U.S., and musculoskeletal conditions cost $215 billion/year. The objectives of this study were to develop moldable/injectable, mechanically strong and in situ-hardening calcium

Combinatorial Polymer Scaffold Libraries for Screening Cell-Biomaterial Interactions in 3D

June 4, 2008

Author(s)

Yanyin Yang, Matthew Becker, J Kohn, Carl G. Simon Jr.

Combinatorial methodology, originated from the drug discovery process, have generated numerous interests in modern materials science in terms of reducing costs of experimentation and accelerating research progress. In developing new biomaterials for tissue