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Search Publications by: Yun Liu (Fed)

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Displaying 26 - 50 of 104

Intermediate Scattering Functions of a Rigid Body Monoclonal Antibody Protein in Solution Studied by Dissipative Particle Dynamic Simulation

April 8, 2021
Author(s)
Yanqin Zhai, Nicos Martys, William L. George, Joseph E. Curtis, Jannatun Nayem, Y. Z, Yun Liu
In the past decade, there is increased research interest in studying internal motions of flexible proteins in solution using Neutron Spin Echo (NSE) as NSE can simultaneously probe the dynamics at the length and time scale comparable to protein domain

Molecular View on Mechanical Reinforcement in Polymer Nanocomposites

March 16, 2021
Author(s)
Ruikun Sun, Matthew Melton, Niloofar Safaie, Jr. Ferrier, Shiwang Cheng, Yun Liu, Xiaobing Zuo, Yangyang Wang
The microscopic origin of mechanical enhancement in polymer nanocomposites (PNCs) is investigated through the combination of rheology and small-angle neutron scattering. It is shown that in the absence of an extensive particle network, the molecular

Controlling Bicontinuous Structures through Solvent Segregation Driven Gel

February 16, 2021
Author(s)
Yuyin Xi, Juscelino Leao, Qiang Ye, Ronald S. Lankone, Li Piin Sung, Yun Liu
The past decade has seen increased research interests in studying bicontinuous structures formed by the colloidal self-assembly due to their many useful applications. A new type of colloidal gel, solvent segregation driven gel (SeedGel), has been recently

Adsorption of Non-Ionic Surfactant and Monoclonal Antibody on Siliconized Surface Studied by Neutron Reflectometry

February 15, 2021
Author(s)
Zhenhuan Zhang, Ann M. Woys, Kunlun Hong, Christoph Grapentin, Tarik A. Khan, Isidro E. Zarraga, Norman J. Wagner, Yun Liu
The adsorption of monoclonal antibodies (mAbs) on hydrophobic surfaces is known to cause protein aggregation and degradation. Therefore, surfactants, such as Poloxamer 188, are widely used in therapeutic formulations to stabilize mAbs and protect mAbs from

Alignment of Worm-like Micelles at Intermediate and High Shear Rates

February 1, 2020
Author(s)
Brisa Arenas-Gomez, Cristina Garza, Yun Liu, Rolando Castillo
Hypothesis. Rheology combined with Small Angle Neutron Scattering (Rheo-SANS) can determine the local structural order in Worm-like Micelle (WLM) solutions, when the shear rate increases beyond the ending of the gradient shear banding, where the micellar

Dynamic Equivalence between Soft Star Polymers and Hard Spheres

November 19, 2019
Author(s)
Zhe Wang, Antonio Faraone, Panchao Yin, Lionel Porcar, Yun Liu, Changwoo Do, Kunlun Hong, Wei-Ren Chen
We measure a series of star polymer dispersions to study the dynamics of soft colloidal liquids. We find that as the concentration increases, the slowing of the long-time self-diffusivity of the star polymer, normalized by the short-time self-diffusivity

Orientational Distribution Function of Aligned Elongated Molecules and Particulates Determined from Their Scattering Signature

October 15, 2019
Author(s)
Guan-Rong Huang, Yangyang Wang, Changwoo Do, Yuya Shinohara, Takeshi Egami, Lionel Porcar, Yun Liu, Wei-Ren Chen
We present a strategy for quantitatively evaluating the field-induced alignment of non-spherical particles using small angle scattering techniques. The orientational distribution function (ODF) is determined from the anisotropic scattering intensity via

Quantification of a PbCl x Shell on the Surface of PbS Nanocrystals

August 5, 2019
Author(s)
Samuel W. Winslow, Yun Liu, James W. Swan, William A. Tisdale
Differences between the properties of PbS nanocrystals prepared using a large excess of PbCl 2 and those prepared using other Pb sources have led to speculation that a thin PbCl x shell may be present on the surface of PbCl 2-derived PbS nanocrystals

Characterization of Colloidal Nanocrystal Surface Structure using Small Angle Neutron Scattering and Efficient Bayesian Parameter Estimation

June 28, 2019
Author(s)
Samuel W. Winslow, Wenbi Shcherbakov-Wu, Yun Liu, William A. Tisdale, James W. Swan
Complete structural characterization of colloidal nanocrystals is challenging due to rapid variation in the electronic, vibrational, and elemental properties across the nanocrystal surface. while electron microscopy and X-ray scattering techniques can

In Situ Characterization of the Microstructural Evolution of Biopharmaceutical Solid-State Formulations with Implications for Protein Stability

January 7, 2019
Author(s)
Stijn H.S. Koshari, Purnendu K. Nayak, Shalini Burra, Isidro E. Zarraga, Karthikan Rajagopal, Yun Liu, Norman J. Wagner, Abraham M. Lenhoff
Lyophilized and spray-dried biopharmaceutical formulations are used to provide long-term stability for storage and transport, but questions remain about the molecular structure in these solid formulations and how this structure may be responsible for

Neutron Scattering in the Biological Sciences: Progress and Prospects

December 1, 2018
Author(s)
Rana Ashkar, Hassina Z. Bilheux, Heliosa Bordallo, Robert Briber, David J. E. Callaway, Xiaolin Cheng, Xiang-Qiang Chu, Joseph E. Curtis, Mark Dadmun, Paul Fenimore, David Fushman, Frank Gabel, Kushol Gupta, Frederick Herberle, Frank Heinrich, Liang Hong, John Katsaras, Zvi Kelman, Eugenia Kharlampieva, Gerald R. Kneller, Andrey Kovalevsky, Susan T. Krueger, Paul Langan, Raquel Lieberman, Yun Liu, Mathias Losche, Edward Lyman, Yimin NMN Mao, John Marino, Carla Mattos, Flora Meilleur, Peter Moody, Jonathan D. Nickels, William B. O'Dell, Hugh O'Neill, Ursula Perez-Salas, Judith Peters, Loukas Petridis, Alexei P. Sokolov, Robert Sutherland, Norman Wagner, Michael NMN Weinrich, Kevin Weiss, Troy Wymore, Yang Zhang, Jeremy C. Smith
The scattering of neutrons can be used to provide information on the structure and dynamics of biological systems on multiple scales of length and time. Pursuant to an NSF-funded workshop in February 2018, we review recent developments in this field as

Analysis of Small Angle Neutron Scattering Spectra from Deformed Polymers with Spherical Harmonic Expansion Method and a Network Model

November 13, 2018
Author(s)
Zhi-Yuan Wang, Dejia Kong, Lincan Yang, Hongwei Ma, Fengmei Su, Kanae N. Ito, Yun Liu, Xuewu Wang, Zhe Wang
In this paper, we combine the recently proposed spherical harmonic expansion (SHE) method [Phys. Rev. X 2017, 7, 031003] with a modified network model to analyze the small-angle neutron scattering (SANS) spectra from deformed entangled polymers. Focusing

Structure, Rheology, and Microrheology of Wormlike Micelles made of PB-PEO Diblock Copolymers

September 21, 2018
Author(s)
Antonio Tavera-Vazquez, Brisa Arenas-Gomez, Cristina Garza, Yun Liu, Rolando Castillo
A diblock copolymer made of poly(but-2-ene-1,4-diyl)-block-poly(oxyethylene), with a degree of polymerization of the polybutadiene and polyethylene blocks of 37 and 57, respectively, self-assembles in water as worm-like micelles determined with small angle
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