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Search Publications by: Yun Liu (Fed)

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Displaying 51 - 75 of 106

Adsorption of Polysorbate 20 and Proteins on Hydrophobic Polystyrene Surfaces Studied by Neutron Reflectometry

April 21, 2018
Author(s)
Zhenhuan NMN Zhang, Sara V. Orski, Ann Marie Woys, Guangcui Yuan, Isidro E. Zarraga, Norman J. Wagner, Yun Liu
Understanding adsorption of protein and surfactant to hydrophobic surfaces is key for storage stability and delivery of pharmaceutical liquid formulations, because many commonly-used devices, such as drug containers and syringes, have product-containing

Simultaneous Neutron and X-Ray Imaging of 3D Structure of Organic Matter and Fracture in Shales

April 1, 2018
Author(s)
Wei-Shan NMN Chiang, Jacob M LaManna, Daniel S. Hussey, David L. Jacobson, Yun Liu, Jilin Zhang, Daniel T. Georgi, Jordan R. Kone, Jin-hong Chen
Hydrocarbon production from shales using horizontal drilling and hydraulic fracturing has been the key development in the US energy industry in the past decade and has now become more important globally. Nevertheless, many fundamental problems related to

A Non-Invasive Method to Directly Quantify Surface Heterogeneity of Porous Materials

February 22, 2018
Author(s)
Wei-Shan NMN Chiang, Daniel Georgi, Taner Yildirim, Jin-hong Chen, Yun Liu
Many porous materials have widely differing pore surface properties because the matrix materials forming the pores are heterogeneous at microscopic levels resulting in different adsorption/desorption behaviors and storage capacity of guest molecules in

Quasi-Two-dimensional Phase Transition of Methane Adsorbed in Cylindrical Silica Mesopores

November 29, 2017
Author(s)
Daniel W. Siderius, William P. Krekelberg, Wei-Shan NMN Chiang, Vincent K. Shen, Yun Liu
Using Monte Carlo and molecular dynamics simulations, we examine the adsorption of methane in cylindrical silica mesopores in an effort to understand a possible phase transition of adsorbed methane in MCM-41 and SBA-15 silica that was previously identified

Unraveling the Single-Nanometer Thickness of Shells of Vesicle-Templated Polymer Nanocapsules

August 3, 2017
Author(s)
Andrew G.. Richter, Sergey A. Dergunov, Mariya D. Kim, Sergey N. Shmakov, Sai Venkatesh Pingali, Volker S. Urban, Yun Liu, Eugene Pinkhassik
The recent emergence of vesicle-templated nanocapsules as a viable platform for diverse applications has heightened the need for detailed structural characterization of nanocapsule shells and for better understanding of surfactant-mediated directed

Modulation of Polypeptide Conformation through Donor-Acceptor Transformation of Side-Chain Hydrogen Bonding Ligands

July 1, 2017
Author(s)
Ziyuan Song, Rachael A. Mansbach, Hua He, Kuo-Chih Shih, Ryan Baumgartner, Nan Zheng, Xiaochu Ba, Yinzhao Huang, Deepak Mani, Yun Liu, Yao Lin, Mu-Ping Nieh, Andrew L. Ferguson, Lichen Yin, Jianjun Chen
Synthetic polypeptides have received increasing attention due to their ability to form higher ordered structures similar to proteins. The control over their secondary structures, which enables dynamic conformational changes, is primarily accomplished by

Simultaneous Neutron and X-Ray Imaging of 3D Kerogen and Fracture Structure in Shales

June 17, 2017
Author(s)
Wei-Shan NMN Chiang, Jacob M LaManna, Daniel S. Hussey, David L. Jacobson, Yun Liu, Jilin Zhang, Daniel T. Georgi, Jin-hong Chen
Hydrocarbon production from shales using horizontal drilling and hydraulic fracturing has been the key development in US energy industry in the past decade and has now become more important globally. Nevertheless, many fundamental problems related to the

Rheology of clustering protein solutions

July 5, 2016
Author(s)
Vishnu Dharmaraj, P. Douglas Godfrin, Yun Liu, Steven Hudson
High viscosity is a major challenge with protein therapeutics at extremely high concentration. Understanding the relationship between the concentration of a protein solution and its viscosity as a function of shear rate and temperature is therefore

Supramolecular Hydrophobic Aggregates in Hydrogels Partially Inhibit Ice Formation

June 23, 2016
Author(s)
Clinton G. Wiener, Madhu Sudan Tyagi, Yun Liu, R. A. Weiss, Bryan D. Vogt
Prevention of ice crystallization is a challenging problem with implications in diverse applications, including the ability to examine the fundamental low temperature physics of water. Here, we demonstrate a simple route, inspired by water confinement in

Effect of Hierarchical Cluster Formation on the Viscosity of Concentrated Monoclonal Antibody Formulations Studied by Neutron Scattering

January 21, 2016
Author(s)
P. Douglas Godfrin, Isidro E. Zarraga, Jonathan Zarzar, Lionel Porcar, Peter Falus, Norman J. Wagner, Yun Liu
Recently, reversible cluster formation has been identified as an underlying cause of anomalously large solution viscosities observed in some concentrated monoclonal antibody (mAb) formulations. As high solution viscosity prevents the use of subcutaneous

Structural Changes and Aggregation Mechanisms for Anti-Streptavidin IgG1 at Elevated Concentration

December 10, 2015
Author(s)
Gregory V. Barnett, Wei Qi, Samiul Amin, E. Neil Lewis, Vladimir I. Razinkov, Bruce A. Kerwin, Yun Liu, Christopher J. Roberts
Non-native protein aggregation may occur during manufacturing and storage of protein therapeutics, and this may decrease drug efficacy or jeopardize patient safety. From a regulatory perspective, changes in higher-order structure due to aggregation are of

Short-Time Glassy Dynamics in Viscous Protein Solutions with Competing Interactions

November 27, 2015
Author(s)
P. Douglas Godfrin, Steven Hudson, Kunlun Hong, Lionel Porcar, Peter Falus, Norman J. Wagner, Yun Liu
Although there have been numerous investigations of the glass transition for colloidal dispersions with only a short range attraction (SA), less is understood for systems interacting with a SA and an additional longer range repulsion (LR), which is

Direct Observation of Critical Adsorption on Colloidal Particles

August 25, 2015
Author(s)
Christopher E Bertrand, P. D. Godfrin, Yun Liu
Despite the fundamental role adsorbed solvent layers play in generating critical Casimir forces between colloidal particles, the structure of these layers has yet to be directly determined. Using small-angle neutron scattering ,we have measured critical