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Search Publications by: Samantha Maragh (Fed)

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Displaying 1 - 15 of 15

Cybersecurity of Genomic Data

December 20, 2023
Author(s)
Ronald Pulivarti, Natalia Martin, Frederick R. Byers, Justin Wagner, Justin Zook, Samantha Maragh, Jennifer McDaniel, Kevin Wilson, Martin Wojtyniak, Brett Kreider, Ann-Marie France, Sallie Edwards, Tommy Morris, Jared Sheldon, Scott Ross, Phillip Whitlow
Genomic data has enabled the rapid growth of the U.S. bioeconomy and is valuable to the individual, industry, and government because it has multiple intrinsic properties that in combination make it different from other types of high value data which

Fire Burn and Cauldron Bubble: What is in your Genome Editing Brew?

October 28, 2022
Author(s)
Simona Patange, Samantha Maragh
Genome editing is a rapidly evolving biotechnology with the potential to transform many sectors of industry such as agriculture, biomanufacturing, and medicine. This technology is enabled by an ever-growing portfolio of biomolecular reagents that span the

A Roadmap for LIMS at NIST Material Measurement Laboratory

April 11, 2022
Author(s)
Gretchen Greene, Jared Ragland, Zachary Trautt, June W. Lau, Raymond Plante, Joshua Taillon, Adam Abel Creuziger, Chandler A. Becker, Joe Bennett, Niksa Blonder, Lisa Borsuk, Carelyn E. Campbell, Adam Friss, Lucas Hale, Michael Halter, Robert Hanisch, Gary R. Hardin, Lyle E. Levine, Samantha Maragh, Sierra Miller, Chris Muzny, Marcus William Newrock, John Perkins, Anne L. Plant, Bruce D. Ravel, David J. Ross, John Henry J. Scott, Christopher Szakal, Alessandro Tona, Peter Vallone
Instrumentation generates data faster and in higher quantity than ever before, and interlaboratory research is in historic demand domestically and internationally to stimulate economic innovation. Strategic mission needs of the NIST Material Measurement

The NIH Somatic Cell Genome Editing program

April 7, 2021
Author(s)
Samantha Maragh
The move from reading to writing the human genome offers new opportunities to improve human health. The United States National Institutes of Health (NIH) Somatic Cell Genome Editing (SCGE) Consortium aims to accelerate the development of safer and more

Measurement and Standardization Challenges for Exosome-Based Delivery Vectors

September 4, 2020
Author(s)
Bryant C. Nelson, Lili Wang, Samantha D. Maragh, Paul C. DeRose, Elzafir B. Elsheikh, Wyatt N. Vreeland, Ionita Ghiran, Jennifer Jones
Extracellular vesicles (EVs), and in particular exosomes, have the potential to revolutionize the development and efficient delivery of clinical therapeutics. In this Perspective, we focus on providing a brief introduction to the landscape of exosome-based

Evaluation of two mitochondrial DNA biomarkers for prostate cancer detection

August 17, 2015
Author(s)
Samantha D. Maragh, Steven P. Lund
BACKGROUND: A 3.4kb deletion (3.4kbΔ) in mitochondrial DNA (mtDNA) found in histologically normal prostate biopsy specimens has been reported to be a biomarker for the increased probability of prostate cancer. Increased mtDNA copy number is also reported

Rbm24a and Rbm24b are required for normal somitogenesis

August 29, 2014
Author(s)
Samantha D. Maragh
We recently demonstrated that the gene encoding the RNA binding motif protein 24 (Rbm24)¬¬ is expressed during mouse cardiogenesis, and determined the developmental requirement for its zebrafish homologs Rbm24a and Rbm24b during cardiac development. We

Mitochondrial Genome Deletion Aids in the Identification of Both False and True Negative Prostate Needle Core Biopsies

January 6, 2008
Author(s)
Jennifer Maki, Kerry Robinson, Brian Reguly, Jude Alexander, Roy Wittock, A A. Aguirre, Eleftherios Diamandis, Nicholas Escott, Anthony Skehan, Owen Prowse, Robert E. Thayer, Kent Froberg, Michael Wilson, Samantha D. Maragh, J P. Jakupciak, Paul D. Wagner, S Srivastava, Gabriel D. Dakubo, Ryan L. Parr
We report the utility of a 3.4kb mtgenome deletion (3.4mt?) for molecular definition of benign, malignant and proximal to malignant (PTM) needle biopsies. The 3.4mt_ was identified through long extension PCR analysis of frozen PCa samples. A quantitative

Development of genomic reference materials for Huntington disease genetic testing

October 1, 2007
Author(s)
Lisa Kalman, Monique A. Johnson, Jeanne Beck, Elizabeth Berry-Kravis, Arlene Buller, Brett Casey, Gerald L. Feldman, James Handsfield, J P. Jakupciak, Samantha D. Maragh, Karla J. Matteson, Kasinathan Muralidharan, Kristy L. Richie, Elizabeth M. Rohlfs, Fredrick V. Schaefer, Tina Sellers, Elaine B. Spector, C D. Richards

Development of genomic reference materials for Huntington disease genetic testing

October 1, 2007
Author(s)
Lisa Kalman, Monique A. Johnson, Jeanne Beck, Elizabeth Berry-Kravis, Arlene Buller, Brett Casey, Gerald L. Feldman, James Handsfield, J P. Jakupciak, Samantha D. Maragh, Karla J. Matteson, Kasinathan Muralidharan, Kristy L. Richie, Elizabeth M. Rohlfs, Fredrick V. Schaefer, Tina Sellers, Elaine B. Spector, C D. Richards

Analysis of potential cancer biomarkers in mitochondrial DNA

December 1, 2006
Author(s)
J P. Jakupciak, G. D. Dakubo, Samantha D. Maragh, R. L. Parr
Understanding mitochondrial biology is a fundamental research goal in human genetics and medicine. The use of mitochondria to serve as a biomarker is rapidly expanding in disciplines ranging from cancer, rare metabolic diseases, aging, the tracing of human