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Search Publications by: David P. Hoogerheide (Fed)

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Displaying 26 - 45 of 45

Advances in Translational Nanotechnology: Challenges and Opportunities

May 28, 2020
Author(s)
Shyam S. Mohapatra, Robert D. Frisina, Subhra Mohapatra, Kevin B. Sneed, Eleni Markoutsa, Tao Wang, Rinku Dutta, Ratka Damnjanovic, Manh-Huong Phan, Daniel J. Denmark, Manas R. Biswal, Andrew R. McGill, Ryan Green, Mark Howell, Payal Ghosh, Alejandro Gonzalez, Nadia Tasnim Ahmed, Brittney Borresen, Mitchell Farmer, Melissa Gaeta, Krishna Sharma, Christen Bouchard, Danielle Gamboni, Jaime Martin, Bianca Tolve, Mandip Singh, Jack W. Judy, Chenzhong Li, Swadeshmukul Santra, Sylvia Daunert, Elnaz Zeynaloo, Ryan M. Gelfand, Steven Lenhert, Eric S. McLamore, Dong Xiang, Victoria Morgan, Lisa E. Friedersdorf, Ratnesh Lal, Thomas J. Webster, David Hoogerheide, Thanh Duc Nguyen, Martin J. D'Souza, Mustafa Culha, Pierre P. Kondiah, Donald K. Martin

Protein Translocation Activity in Surface-Supported Lipid Bilayers

August 25, 2019
Author(s)
Kanokporn Chattrakun, David Hoogerheide, Chunfeng Mao, Linda L. Randall, Gavin M. King
Surface-supported lipid bilayers are used widely throughout the nanoscience community as robust mimics of cellular membrane. For example, they are frequently employed in single molecule atomic force microscopy (AFM) studies to shed light on membrane

Structural Investigations of Membrane-Associated Proteins by Neutron Reflectometry

July 1, 2019
Author(s)
Rebecca Eells, David Hoogerheide, Paul A. Kienzle, Mathias Loesche, Charles Majkrzak, Frank Heinrich
Neutron reflectometry is a powerful technique for probing the structure of lipid bilayer membranes and membrane-associated proteins. Measurements of the specular neutron reflectivity as a function of momentum transfer can be performed in aqueous

Probing Membrane Association of a-Synuclein Domains with VDAC Nanopore Reveals Unexpected Binding Pattern

March 14, 2019
Author(s)
Daniel Jacobs, David Hoogerheide, Amandine Rovini, Zhiping Jiang, Jennifer C. Lee, Tatiana K. Rostovtseva, Sergey M. Bezrukov
It is well established that α-synuclein (α-syn) binding from solution to the surface of membranes composed of negatively charged and/or non-lamellar lipids can be characterized by equilibrium dissociation constants of tens of micromolar. Previously, we

Porous Zero-Mode Waveguides for Picogram-Level DNA Capture

February 13, 2019
Author(s)
Vivek Jadhav, David Hoogerheide, Jonas Korlach, Meni Wanunu
We have recently shown that nanopore zero-mode waveguides are effective tools for capturing picogram levels of long DNA fragments for single-molecule DNA sequencing. Despite these key advantages, manufacturing of large arrays is not practical due to the

Optimization of Reflectometry Experiments using Information Theory

February 1, 2019
Author(s)
Bradley W. Treece, Paul A. Kienzle, David Hoogerheide, Charles Majkrzak, Mathias Loesche, Frank Heinrich
A method based on Bayesian statistics and information theory is developed to analyze the information gain Δ}H of surface-sensitive reflectometry experiments. After presenting the underlying mathematical framework and its implementation, the method is

Real-Time Nanopore-Based Recognition of Protein Translocation Success

February 27, 2018
Author(s)
David Paul Hoogerheide, Philip A. Gurnev, Tatiana K. Rostovtseva, Sergey M. Bezrukov
A growing number of new technologies are supported by a single- or multi-nanopore architecture for capture, sensing, and delivery of polymeric biomolecules. 1-6 Nanopore-based single-molecule DNA sequencing, in which engineered nanopores 7 are augmented

Structural Features and Lipid Binding Domain of Tubulin on Biomimetic Mitochondrial Membranes

April 18, 2017
Author(s)
David Paul Hoogerheide, Sergei Y. Noskov, Daniel Jacobs, Lucie Bergdoll, Vitalii Ivanovich Silin, David L. Worcester, Jeff Abramson, Hirsh Nanda, Tatiana K. Rostovtseva, Sergey M. Bezrukov
Amphitropic proteins, the subfamily of peripheral membrane proteins that interact directly with lipid bilayers, comprises members whose function depends on their localization either in the cytosol or at the cellular membranes. Despite the well-established

Conductance Hysteresis in the Voltage-Dependent Anion Channel

September 1, 2015
Author(s)
Shay M. Rappaport, Oscar Teijido, David Hoogerheide, Tatiana K. Rostovtseva, Alexander M. Berezhkovskii, Sergey M. Bezrukov
In contrast to the voltage gating of ion-selective channels of electrophysiology, the mechanisms of voltage sensitivity of ¿large¿ beta-barrel channels remain obscure, even at the conceptual level. Here we study hysteresis in the conductance response of