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Displaying 1 - 4 of 4

Activity standard and calibrations for 227Th with ingrowing progeny

April 20, 2024
Author(s)
Denis E. Bergeron, Jeffrey T. Cessna, Brittany Broder, Leticia Pibida, Ryan P. Fitzgerald, Morgan DiGiorgio, Elisa Napoli, Brian E. Zimmerman
Thorium-227 was separated from its progeny and standardized for activity by the triple-to-double coincidence ratio (TDCR) method of liquid scintillation counting. Confirmatory liquid scintillation-based measurements were made using efficiency tracing with

Efficient Synthesis and HPLC-Based Characterization for Developing Vanadium-48-Labeled Vanadyl Acetylacetonate as a Novel Cancer Radiotracer for PET Imaging

February 9, 2024
Author(s)
Brittany Broder, Mohammed Bhuiyan, Richard Freifelder, David Rotsch, Satish Chitneni, Marvin William Makinen, Chin-Tu Chen
Bis(acetylacetonato)oxidovanadium(IV) [(VO(acac)2], generally known as vanadyl acetylacetonate, has been shown to be preferentially sequestered in malignant tissue. Vanadium-48 (48V) generated with a compact medical cyclotron has been used to label VO(acac

Accelerator-Based Production of Scandium Radioisotopes for Applications in Prostate Cancer: Toward Building a Pipeline for Rapid Development of Novel Theranostics

August 13, 2023
Author(s)
Jason Meier, Hannah Zhang, Richard Freifelder, Mohammed Bhuiyan, Phillip Selman, Megan Mendez, Pavithra Kankanamalage, Thomas Brossard, Antonino Pusateri, Hsiu-Ming Tsai, Lara Leoni, Sagada Penano, Kaustab Ghosh, Brittany Broder, Erica Markiewicz, Amy Renne, Walter Stadler, Ralph Weichselbaum, Jerry Nolen, Chien-Min Kao, Satish Chitneni, David Rotsch, Russell Szmulewitz, Chin-Tu Chen
In the field of nuclear medicine, the β+ emitting 43Sc and β- emitting 47Sc are promising candidates in cancer diagnosis and targeted radionuclide therapy (TRT) due to their fa-vorable decay schema and shared pharmacokinetics as a true theranostic pair