Bioimaging

Orthogonal Measurements

Ongoing

Definitions: Orthogonal measurements: Measurements that use different physical principles to measure the same property of the same sample with the goal of minimizing method-specific biases and interferences. Complementary measurements: Measurements that corroborate each other to support the same

Quantitative, Traceable Determination of Cell Viability Using Absorbance Microscopy

Ongoing

The current gold standard for cell viability measurements is the trypan blue assay. Trypan blue dye enters dead cells that have a ruptured membrane. As a result, the dead cells are stained blue. Live cells with an intact membrane, on the other hand, do not absorb the dye molecules and remain

RMAT Laboratory Programs

Ongoing

Examples of Current Activities: Cell Counting and viability are key measurements critical for decision making from R&D to manufacturing. We recently developed an approach for evaluating the quality of cell counting measurements through experimental design and statistical analysis that does not

Series of MRI images labeled A to E showing different views of brain tissue, some with gadolinium highlighted in blue against a purple background.

Understanding the Bioaccumulation of Gadolinium-Based Contrast Agents using Advanced Measurement Capabilities

Ongoing

Researchers and staff from the Medical University of South Carolina are collaborating with NIST staff experienced in trace elemental speciation, sample preparation and instrumental analysis in order to demonstrate the bioaccumulation of intact GBCA in patients who have repeated GBCA exposure

News and Updates

A hand in a purple glove turns a metal dial on a plate holding tiny vials of purple liquid.

Bioimaging

The Research

Orthogonal Measurements

Quantitative, Traceable Determination of Cell Viability Using Absorbance Microscopy

RMAT Laboratory Programs

Understanding the Bioaccumulation of Gadolinium-Based Contrast Agents using Advanced Measurement Capabilities

News and Updates

NIST Develops New Nondestructive Method for Assessing Bioengineered Artificial Tissues

A Recap of TMAP

NIST Scientists and Engineers Pitch Innovations to Venture Capitalists