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Breast-conserving surgery, or lumpectomy, is a treatment for early-stage breast cancer. It’s important for surgeons to remove enough tissue around the tumor to
“Only connect” is the most famous line in the British novelist E. M. Forster’s writings. Forster was urging the readers of his book Howard’s End to make
Researchers at the National Institute of Standards and Technology (NIST) and colleagues have developed a novel, anatomically accurate reference model of the
This project aims to develop light-scattering microscopy methods for rapid, multi-attribute characterization of gene therapy particles at the single particle level. Emerging gene therapy treatments use gene delivery particles, such as viral vectors and non-viral carriers, to cure intractable
Use of synthetic cell membrane mimics allow simplification and complete control of a complicated system, and incorporation of selected elements under physiological conditions. We are furthering a technology originally developed at NIST using model lipid membranes supported on surfaces for
Terahertz radiation interrogates the lowest frequency vibrational modes of a biomolecule. These modes characterize the incipient motions for large-scale conformational changes responsible for the backbone flexibility of protein, polynucleotide and polysaccharide. Thus, terahertz spectral features
Cellular remodeling of their neighboring environment, extracellular matrix (ECM), is an important biological process from development biology, to wound healing, to diseases and cancers – this is a challenging process to measure and quantify. Surface plasmon resonance imaging (SPRI) has been
Xiaojun Wei, Dumei Ma, Junlin Ou, Ge Song, Jiawei Guo, Joseph Robertson, Yi Wang, Qian Wang, Chang Liu
Nanopores have demonstrated remarkable sensitivity as biosensors, enabling the sequencing of DNA and RNA at the single-molecule level. The rapid progress in
Enumeration of bacterial colonies on an agar plate is simple in concept, but automated colony counting is difficult due to variations in colony color, size
MOSAIC is a modular single-molecule analysis toolbox to decode multi-state single-molecule and nanopore time-series data. Read the documentation for additional