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Displaying 1 - 25 of 196

JBO Special Issue on Hyperspectral Imaging

March 4, 2025
Author(s)
Baowei Fei, Jeeseong Hwang, Matija Milanic
The editors introduce a Journal of Biomedical Optics (JBO) feature issue on "Hyperspectral imaging." The special issue features a number of important research and review papers on new hyperspectral imaging and detection devices and associated technologies

Engineering Nanopore Approaches toward Protein Sequencing

July 25, 2023
Author(s)
Xiaojun Wei, Tadas Penkauskas, Joseph Reiner, Mark Uline, Qian Wang, Sheng Li, Aleksei Aksimentiev, Joseph Robertson, Chang Liu
Biotechnological innovations have vastly improved the capacity to perform large-scale protein studies, while the methods we have of identifying and quantifying individual proteins are still inadequate to perform protein sequencing at the single-molecule

Microfluidic techniques for mechanical measurements of biological samples

January 20, 2023
Author(s)
Paul Salipante
The use of microfluidics to make mechanical property measurements is increasingly common. Fabrication of microfluidic devices has enabled various types of flow control and sensor integration at micrometer length scales to interrogate biological materials

Polydimethylsiloxane tissue-mimicking phantoms with tunable optical properties

July 1, 2022
Author(s)
Aaron Goldfain, Paul Lemaillet, David W. Allen, Kimberly Briggman, Jeeseong C. Hwang
We report on techniques to manufacture and characterize solid tissue-mimicking phantoms of polydimethylsiloxane (PDMS) polymers. Tunability of the absorption (a()) and reduced scattering spectra (s'()) in the wavelength range of 500 nm to 850 nm is

NIST Traveling Tunable Laser Projector (TTLP) for UV-Blue Disinfection Dose Determinations

June 21, 2022
Author(s)
Thomas C. Larason, Steven Grantham, Clarence Zarobila, Yuqin Zong, C Cameron Miller, Michael Schuit, Brian Holland, Stewart Wood, Melissa Krause
As COVID-19 was overtaking the world in the spring of 2020, the National Institute of Standards and Technology began collaborating with the National Biodefense Analysis and Countermeasures Center to study the inactivation of SARS-CoV-2 to different UV and

The Structure of Lipids and Keratin in Adhesive Gecko Setae Determined by NEXAFS Imaging

March 1, 2022
Author(s)
Daniel A. Fischer, Cherno Jaye, Katinka R. Holler, Mette H. Rasmussen, Joe E. Baio, Stanislav N. Gorb, Tobias Weidner
Geckos have the astonishing ability to climb on vertical surfaces due to the adhesive properties of fibrous setae at the tips of their toe pads. While the adhesion mechanism principle, based on van-der-Waals interactions of myriads of spatula located at

Micromechanical Compatibility Between Cells and Scaffolds Directs Phenotypic Transition of Stem Cells

January 28, 2022
Author(s)
Yang Song, Jiaoyue Long, Jeremiah Woodcock, Joy Dunkers, Hung Chun Lin, Douglas M. Fox, Xiaoling Liao, Yonggang Lv, Li Yang, Martin Chiang
This study experimentally substantiates the micromechanical compatibility between cell and substrate is essential for cells to achieve energetically favorable mechanotransduction that directs phenotypic transitions. The argument for this compatibility is

Quantification of urban biogenic carbon fluxes using bottom-up inventory and satellite-based model

January 5, 2022
Author(s)
Joy Winbourne, Hrstiana Stoynova, Ian Smith, Conor Gately, Barry Logan, Jaret Reblin, Andrew Reinmann, David W. Allen, Lucy Hutyra
Cities across the globe are taking the lead on climate mitigation action with ambitious goals to reduce carbon dioxide (CO2) emissions. The implementation of effective mitigation policies will require accurate measurements to guide policy decisions and

HDX-MS and MD simulations provide evidence for stabilization of the IgG1- FcgRIa (CD64a) immune complex through intermolecular glycoprotein bonds

December 8, 2021
Author(s)
Kyle Anderson, Kerry Scott, Christina Bergonzo, Ioannis Karageorgos, Elyssia Gallagher, Venkata Tayi, Michael Butler, Jeffrey W. Hudgens
Previous reports present different models for the stabilization of the Fc—FcγRI immune complex. Although accord exists on the importance of L235 in IgG1 and some hydrophobic contacts for complex stabilization, discord exists regarding the existence of

Blood vessel-on-a-chip examines biomechanics of microvasculature

November 15, 2021
Author(s)
Paul Salipante, Steven D. Hudson, Styliani Alimperti
We use a three-dimensional (3D) microvascular platform to measure the elasticity and membrane permeability of the endothelial cell layer. The microfluidic platform is connected with a pneumatic pressure controller to apply hydrostatic pressure. The

Nanopore sensing: a physical-chemical approach

September 1, 2021
Author(s)
Joseph W. Robertson, Madhav Ghimire, Joseph Reiner
Protein nanopores have emerged as an important class of sensor, for the understanding of biophysical processes, such as molecular transport across membranes, and detection and characterization of biopolymers. We trace the development of these sensors from
Displaying 1 - 25 of 196