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Chemistry

Projects/Programs

Displaying 126 - 150 of 173

Protein Preservation

Completed
This project is an integral part of a cooperative effort – led by NIST, and partially funded by NIH/ NIBIB – which includes the University of Wisconsin, the University of Colorado, and the University of Connecticut. We use the following approach to develop measurement solutions for biopharmaceutical

Quantitative Flow Cytometry Measurements

Ongoing
Flow cytometry is an essential tool for: basic biotechnological and immunological research, the clinical discovery of potential therapeutics, development and approval of drugs and devices, disease diagnosis, and therapeutic treatment and monitoring For example, flow cytometry is commonly used in pre

Quantum Bioimaging

Ongoing
Our efforts in BBD are focused on using the quantum nature of light to facilitate enhanced and novel measurement technologies for biological samples. For example, so-called bright squeezed laser sources enable imaging and sensing with less noise than is classically possible. Additionally, entangled
Nanoparticles labeled infographic. Microscopic element vector illustration.

Reactivity of Nanoparticle Catalysts

Ongoing
Goals: Provide mechanisms for various prototypical electrocatalytic reactions on different metallic surfaces an nanoparticles. Validate the results of DFT calculations versus experimental data. Research Activities: Studying the methanol oxidation reaction on Pt and PtRu surfaces. Studying the effect
Photograph of a long pink flame against a black background, emanating from a torch, with small blue cone near the base of the nozzle.

Real Fuels

Ongoing
The variability of the price of oil, the need for energy efficiency and pollution minimization has led to increasing interest in alternative fuels. These fuels are structurally and compositionally different than the conventional fuels presently used.  Past work on conventional fuels have established
Color coded refrigerant bottles

Refrigerants and Working Fluids

Ongoing
We apply a wide range of experimental apparatus to the task of measuring the properties of working fluids. Many of these instruments are the same as those used in our work on standard reference fluids, and our data for working fluids approach the accuracy of the reference fluids. Thermodynamic

Renewable Energy and Fuels

Ongoing
Fuel volatility and chemical characterization. We specialize in the Advanced Distillation Curve (ADC) method, developed at NIST, which is a powerful tool for the measurement of distillation curves to characterize complex fluids. We have applied this to simple hydrocarbons, gasolines, diesel fuels

Renewable Polymers

Completed
In this project, use innovative measurements to optimize existing materials synthesis and discover new routes to polymers from renewable feedstocks by providing characterization methods that can describe the mechanisms and of enzymatic catalysis of polymers from renewable feedstocks and synthetic

Secondary Ion Mass Spectrometry Ion Source Development

Ongoing
In SIMS, a typical analysis requires <1% of the surface to be sampled, which minimizes chemical damage in the form of molecular fragmentation due to energetic ion bombardment. Cluster sources such as C 60 and Ar GCIB allow for efficient removal of the damage volume, and by operating the analysis and

Semiconductor Nanowire Metrology: Electronics, Photonics, and Sensors

Completed
One of the key issues hampering progress in semiconductor nanotechnology is the absence of standardized nanostructures. We address this need through the controlled fabrication and assembly of semiconductor nanowire test structures with well-defined properties. To achieve this, we have manufactured
nanopore event

Single-molecule biosensors

Ongoing
We are developing new tools to investigate the energy landscape of single-molecule sensors. Our goal is to apply a wide-ranging array of technologies to probe the critical physicochemical properties of nanopore biosensors. These properties include the free energy of confinement for polymers as they

Special Functions

Ongoing
Special function evaluation is among the more venerable problems of numerical mathematics and remains a staple for engineers, physicists, and scientific computation. What is more, the need for detailed numerical evaluations grows steadily as new quantitative theories are developed for an increasing

Springback

Ongoing
Springback, or the elastic change in shape when a part is released from the manufacturing process, has been a problem for decades and accounts for a significant fraction of the expense that the US auto industry spends each year trying out die sets for new body designs. The inability to predict the
Photograph of a packaged unit of SRM 2700 Hexavalent chromium in Contaminated Soil (low Level)

Standard Reference Materials for Hexavalent Chromium in Contaminated Soil

Completed
During the last century, chromate and dichromate chemical production facilities processed considerable amounts of chromite ore for industrial manufacturing purposes. The waste material from these operations called chromite ore processing residue (COPR) was disposed of in waste sites across the
drop

Standard Reference Measurements

Ongoing
State-of-the art property measurements have been the hallmark of the Fluid Properties Group for more than four decades. Many of these measurements have been carried out on one-of-a-kind instruments developed at NIST. In some cases the older instruments are still among the very best of their kind
Photograph of SRM 3103a showing a labeled clear glass ampoule and labeled box against a blue background.

Standard Solution SRMs Provide Traceability for Millions of Measurements

Ongoing
Literally millions of measurements of elemental composition are performed each year worldwide. The vast majority of these measurements depend upon reference materials for establishing traceability of results to the SI. Leveraged through commercial CRM producers, the NIST SRM 3100 series provides an

Standards

Ongoing
Standards for Optical Based Standoff Detection NIST is researching methods for creating explosive threat materials standards relevant to optical detection technologies (e.g. that result in samples with particle morphologies similar to those found in explosive threat devices). This includes both
Breathalyzer

Standards Development to Ensure Reliable Breath Analysis in the Field

Ongoing
Numerous volatile organic compounds (VOCs) have been identified in human breath. These compounds can be produced by the body or by organisms in the body (e.g., bacteria or viruses) and provide a non-invasive window into human health. Inexpensive point-of-care devices are being developed to diagnose
testmachine_s

Structure-Property Links in Deformation of Materials

Ongoing
The fundamental physics of the deformation process in metals is controlled by crystal plasticity, a type of non-recoverable strain whose evolution depends on the deformation history of the material (as in all plastic processes), and the relative orientation of the applied load and the crystalline

Study of Microheterogeneity in Solid Reference Materials

Ongoing
Presently there are a variety of analytical techniques that are served by few or no reference materials due to the small sample sizes they require. NIST currently certifies solid reference materials at or above the 100 mg mass level in most cases with no mention of the effect of using smaller sample