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Projects/Programs

Displaying 1 - 9 of 9

Cancer Genome in a Bottle

Ongoing
Goals: This project is an extension of the Genome in a Bottle Consortium to develop the technical infrastructure (reference standards, reference methods, and reference data) to enable translation of cancer genome sequencing to clinical practice and innovations in technologies. The priority of GIAB

Engineering Living Measurement Systems to Sense PFAS

Ongoing
Per- and polyfluoroalkyl substances, PFAS, are thermodynamically stable organic fluorinated chemicals that are resistant to traditional degradation pathways leading to concern for bioaccumulation. These compounds originate from several industrial manufacturing processes and are found in soil systems

External RNA Controls Consortium

Completed
While early gene expression measurements with DNA microarrays were groundbreaking in their ability to reveal biological activity, the results were irreconcilable and irreproducible. Industry leaders approached the National Institute of Standards and Technology (NIST) in 2003 for help with addressing

Genome in a Bottle

Ongoing
Consortium goals: The Genome in a Bottle Consortium is a public-private-academic consortium hosted by NIST to develop the technical infrastructure (reference standards, reference methods, and reference data) to enable translation of whole human genome sequencing to clinical practice and innovations

Measuring Antimicrobial Resistance

Ongoing
Antibiotic resistance has been identified in the Nation’s Action Plan to improve the health and wellbeing of the American people. NIST scientists are leveraging a wide range of measurement capabilities to study microbial community dynamics with regard to antimicrobial resistance. Using a range of

Methods for Absolute Quantitation of Transcription

Ongoing
The ability to engineer novel, useful functions into microbial cells for manufacturing or therapeutic applications has accelerated rapidly over the last few decades. However, the measurements required to underpin predictive engineering of these systems are typically not comparable across different

Molecular Innovation in Agriculture

Ongoing
Plant science and breeding aim to develop new plant phenotypes with desired qualities, increased production, disease resistance, and traits that mitigate the effects of climate change. At the federal level in the US, plant research is conducted by the USDA's Animal and Plant Health Inspection

RNA Computation and Metrology for Engineering Biology

Ongoing
RNA computation RNA computation, i.e., programmed interactions between RNA molecules that process information, is an increasingly useful synthetic biology tool with applications spanning in vitro biosensing, synthetic cells, and cellular control. We have developed cotranscriptionally encoded RNA

Single-Cell Manipulation and Measurement

Ongoing
Mammalian cells are an important source material for applications in regenerative medicine, gene therapy, engineering biology, and genome editing. Traditional tools for manipulating mammalian cells operate at a bulk cell population level without precision manipulation of individual cells