Biological physics

News and Updates

Spotlight: Game-Changing Microscopy Technique for Identifying Cancerous Cells

September 3, 2024

Breast-conserving surgery, or lumpectomy, is a treatment for early-stage breast cancer. It’s important for surgeons to remove enough tissue around the tumor to

NIST Researchers Develop a Breakthrough COVID-19 Detection Technology

October 2, 2023

“Only connect” is the most famous line in the British novelist E. M. Forster’s writings. Forster was urging the readers of his book Howard’s End to make

white matter mimic in the bottom half of the artificial cranium

Lessons from an Experimental Brain Phantom

July 12, 2023

Researchers at the National Institute of Standards and Technology (NIST) and colleagues have developed a novel, anatomically accurate reference model of the

Projects and Programs

viral vector illustration with RNA seen within the capsid

Gene Delivery Particle Analysis with High-Throughput Light Scattering Microscopy

Ongoing

This project aims to develop light-scattering microscopy methods for rapid, multi-attribute characterization of gene therapy particles at the single particle level. Emerging gene therapy treatments use gene delivery particles, such as viral vectors and non-viral carriers, to cure intractable

Optical medical imaging

Optical medical imaging technologies proliferate in academic research and yet very few translate into the clinic. Optical techniques have high spatial and spectral resolution, lends itself to portability, and inexpensive relative to conventional imaging modalities such as MRI (Magnetic Resonance

Medical (Archive): Workshop for Radiobiology Dosimetry Standardization

Completed

Workshop Agenda with Presentations RADIATION DOSE IS MORE THAN A NUMBER! National Institute of Standards and Technology 100 Bureau Drive, Gaithersburg, MD Green Auditorium September 15 and 16, 2011 THURSDAY, SEPTEMBER 15, 2011 Welcome and Introduction Lisa Karam, NIST Bert Maidment, NIAID Norm

Protocol for Preparing Fibrillar Collagen Matrices on Untreated Polystyrene Labware (Petri)*: A Potential Reference Extracellular Matrix With Robust and Reproducible Cell Responses

Ongoing

Preparation of matrices on a polystyrene surface 1.) Remove DPBS (1x), DPBS (10x), 0.1 M sodium hydroxide, collagen stock from 4 °C storage. 2.) Setup workspace in sterile hood with an appropriate workflow (example shown in Figure 1). 3.) Prepare Collagen Solution. Note: either mix this quickly, or

Publications

Quantifying a light-induced energetic change in bacteriorhodopsin by force spectroscopy

February 7, 2024

Author(s)

David Jacobson, Thomas T. Perkins

Influence of fluorescence lifetime selections and conformational flexibiiliy on brightness of FusionRed variants

February 5, 2024

Author(s)

Srijit Mukherjee, Nancy Douglas, Ralph Jimenez

Excited State Vibrational Dynamics Reveals a Photocycle That Enhances the Photostability of the TagRFP-T Fluorescent Protein

January 28, 2024

Author(s)

Atsushi Yabushita, Ying Kuan Ko, Takayoshi Kobayashi, Izumi Iwakura, Ralph Jimenez

Narrowing Signal Distribution by Adamantane Derivatization for Amino Acid Identification Using α-Hemolysin Nanopore

January 24, 2024

Author(s)

Xiaojun Wei, Dumei Ma, Junlin Ou, Ge Song, Jiawei Guo, Joseph Robertson, Yi Wang, Qian Wang, Chang Liu

Nanopores have demonstrated remarkable sensitivity as biosensors, enabling the sequencing of DNA and RNA at the single-molecule level. The rapid progress in

Software

NIST's Integrated Colony Enumerator (NICE)

January 4, 2021

Enumeration of bacterial colonies on an agar plate is simple in concept, but automated colony counting is difficult due to variations in colony color, size

MOSAIC

MOSAIC is a modular single-molecule analysis toolbox to decode multi-state single-molecule and nanopore time-series data. Read the documentation for additional