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Alexander Peterson (Fed)
Research Chemist
Research Interests:
My research focuses on the development of high-throughput light scattering microscopy methods for the rapid and comprehensive characterization of gene therapy particles at the single-particle level. Gene delivery particles, including viral vectors and non-viral carriers, are pivotal in the treatment of previously intractable diseases. However, the small size (20-200 nm) and complexity of these nano-bioparticles pose significant challenges in production and accurate characterization, leading to issues of heterogeneity that can affect the efficacy and safety of treatments.
To address these challenges and accelerate the development of effective therapies, I am working on innovative light-scatter-based optical microscopes. These advanced tools aim to provide detailed physical measurements—such as mass, size, concentration, and composition—of individual gene delivery particles. By enhancing the precision and efficiency of particle characterization, my research contributes to the improvement of treatment outcomes and safety in the rapidly growing gene therapy field, which is projected to reach a $13 billion market with a 27.8% annual growth rate in 2024. This aligns with broader program goals at NIST, which focuses on advanced characterization approaches for critical quality attributes in gene delivery systems.
I have also worked with physical microscopy techniques such as surface plasmon resonance imaging, quantitative phase imaging, and enhanced darkfield imaging.
Research Areas:
Research Opportunities
2-year fellowship at NIST on the topic of:
- Novel Light Scattering Imaging to Measure the Mass of Gene Delivery Particles
- Advancing Cell-Based Viral Infectivity Assays: Enhancing Reproducibility and Automation
- Advanced Imaging Tools to Measure Dynamics of Pluripotency and Differentiation
Contact alexander.peterson [at] nist.gov (Alexander Peterson) if interested in applying and writing a proposal (3000 words). Application deadlines Feb. 1 and Aug. 1. Open to U.S. citizens, $82,764 stipend plus benefits, relocation expenses included.