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John P. Marino (Fed)

Director, Biotechnology Accelerator

Dr. John P. Marino is the Director of the Biotechnology Accelerator at the National Institute of Standards and Technology (NIST), where he leads the NIST program in research, development and deployment of technologies for biotechnology and advanced biomanufacturing. Prior to this role, Dr. Marino has over 25 years of experience in leading a broad portfolio of biotechnology and biomanufacturing research and development programs as a NIST Senior Research Scientist, Associate Director and Fellow of the Institute for Bioscience and Biotechnology Research (IBBR), a joint research institute of the University of Maryland and NIST and acting Director of the Center for Biomanufacturing and Biomeasurement Innovation (CBBI) at IBBR. Dr. Marino completed his PhD in Biophysical Chemistry at Yale University in 1995 and then held an Alexander von Humboldt postdoctoral fellowship at the Goethe Universität in Germany before he joined NIST in 1997. He holds an Adjunct Professor in the Department of Chemistry and Biochemistry at the University of Maryland and is a recognized leader in precision measurements for biomolecular structure and dynamics and standards development for biomanufacturing.

Publications

Patents (2018-Present)

Amino Acid-Specific Binder And Selectively Identifying An Amino Acid

NIST Inventors
John P. Marino and Zvi Kelman
N-terminal amino acid binding (NAAB) reagents are a tool for parallel, high-throughput proteomics. Afluorescently-labeled NAAB allows immobilized peptides to be identified by their N-terminal residues using single-molecule fluorescent microscopy, which enables novel proteomic analysis, like

Amino Acid-specific Binder and Selectively Identifying an Amino Acid

NIST Inventors
Zvi Kelman and John P. Marino
One of the central challenges in the development of single-molecule protein sequencing technologies is achieving high- fidelity, sequential recognition and detection of specific amino acids that comprise the peptide sequence. The N-End Rule Pathway adaptor protein ClpS, natively recognizes N
Created June 18, 2019, Updated August 7, 2026
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