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Search Publications

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Displaying 1 - 25 of 1297

Tunable protein expression strength with toehold exchange riboregulators

October 4, 2026
Author(s)
Samuel Schaffter, Fernanda Piorino Macruz de Oliveira, Eugenia Romantseva
Toehold exchange (THE) riboregulators are a class of RNA molecules that use toehold-mediated strand exchange (TMSE) to regulate protein translation. The mechanism of TMSE offers many design parameters for precisely tuning the strength of protein expression

What's next for metabolomics?

September 17, 2026
Author(s)
Tracey Johnston, Corey Broeckling, Clary Clish, Valerie Copie, Arthur S. Edison, Ulrich Gunther, Ewy Mathe, Vanessa Phelan, Robert Powers, Daniel Raftery, Nichole Reisdorph, Dajana Vuckovic, David S Wishart, Elizabeth Want
Metabolomics has become a mainstream approach that examines the metabolic composition of biological systems in relation to their physiological and disease states. Using analytical techniques such as nuclear magnetic resonance spectroscopy and mass

The need for standardization and improved open (meta)data practices in metaproteomics

July 26, 2026
Author(s)
Tim Van Den Bossche, Kay Schallert, Jean Armengaud, Zhibin Ning, Daniel Figeys, Pratik Jagtap, Benoit Kunath, Lucia Grenga, Juan Antonio Vizcaino, Benjamin Neely, Leyuan Li, Drik Benndorf, Nico Jehmlich, Paul Wilmes, Robert Hettich, Jana Seifert, Sergio Uzzau, Mary Lipton, Manuel Kleiner, Magnus Arntzen, Lennart Martens, Robert Heyer
Metaproteomics enables functional insight into microbial communities by identifying and quantifying proteins in complex samples. Yet, heterogeneous analytical workflows and the lack of standardization across experimental and bioinformatics stages hinder

Site-Specific Glycosylation Profiling of Protein Subunit and Inactivated Virus Vaccines

July 22, 2026
Author(s)
Zachary Goecker, Meghan Burke Harris, Yi Liu, Yuri Mirokhin, Sergey Sheetlin, Guanghui Wang, Dmitrii Tchekhovskoi, Xiaoyu Yang, Stephen Stein
Background/Objectives: Glycosylation can affect vaccine antigen structure and function, making site-specific glycan characterization relevant to antigen quality and comparability. However, quantitative approaches for comparing glycan microheterogeneity

A cross-vertebrate brain protein interaction map identifies conserved neural and non-neural complexes

June 23, 2026
Author(s)
Vy Dang, Brittney Voigt, David Yang, Gabriel Hoogerbrugge, Muyoung Lee, Rachael Cox, Ophelia Papoulas, Claire McWhite, Raksha Pradeep, Janelle Leggere, Benjamin Neely, Ryan Gray, Edward Marcotte
Protein-protein interactions underlie core brain functions, including neurotransmitter release, receptor activation, and intracellular signaling. Here, we present a compendium of protein-protein interactions conserved across vertebrate brains, spanning

Photopolymer Additive Manufacturing 2025 Workshop Report: Building a Unified Vision from Research to Regulation

June 10, 2026
Author(s)
Callie Higgins, Jason Killgore, Mike Idacavage, Vince Anewenter, Mickey Fortune, Gary Cohen, Perri Katzman, Jessica Hemond, Spencer Loveless, Michael Gould
The third biannual Photopolymer Additive Manufacturing Alliance Workshop was held on September 15-16, 2025, at the University of Colorado Boulder to continue its mission of advancing photopolymer additive manufacturing (PAM). Building on the 2023 PAMA

Procedural Rigor and Reproducibility in NMR Metabolomics: Community Practices and Challenges

May 22, 2026
Author(s)
Tracey Johnston, Leo Cheng, Anastasios Theodorou, Marie Phelan, Goncalo J Gouveia, Robert Powers, Panteleimon Takis, Fabio Casu, Robert Brua, Gagandeep Kaur, Wimal Pathmasiri, Teklab Gebregiworgis, Valerie Copie
Nuclear magnetic resonance (NMR) spectroscopy is a fundamental tool of metabolomics, valued for its reproducibility, quantitative accuracy, and broad applicability across biological and clinical sciences. However, despite its strengths, methodological

Development, characterization, and inter-laboratory validation of methylated human cell free DNA candidate reference materials

May 18, 2026
Author(s)
Zhiyong He, Hua-Jun He, Kenneth Cole, Yves Konigshofer, Russell Garlick, Jayanthi Ramprakash, Matthew Young, Eric Hall, Adam Corner, Michelle Clarissa, Jocelyn Wright, Victoria Cannon, Ming Yu, William Grady, Cecilia Yeung, Zachary Heimer, Zhili Wang, ShiPing Zou, Shidong Jia, Fang Liu, Giancarlo Bonora, Karol Bomsztyk, Daniel Mar
Aberrant DNA methylation biomarkers have demonstrated potential for early cancer detection, multicancer detection, and determining the tissue of origin. Due to their stability, frequency, and accessibility in bodily fluids, circulating cell-free DNA (cfDNA

Beyond Sequence Similarity: The Case for Function-Based Screening of Nucleic Acid Synthesis

May 13, 2026
Author(s)
Gary Able, Tessa Alexanian, Jacob Beal, James Diggans, Kevin Flyangolts, Gene D. Godbold, Eric Horvitz, Bin Hu, Caitlin Jagla, Rassin Lababidi, Brittany Rife Magalis, Sebastian Rivera, Bruce Wittmann, Samuel Forry, David Ross, Sheng Lin-Gibson, Samuel Curtis
Synthetic nucleic acids are a key input to modern biotechnology, yet they represent dual-use materials that require robust screening to mitigate biosecurity risks. The prevailing screening paradigm identifies sequences of concern (SoCs) through sequence

Applying microbial ecology frameworks to microbial therapies for wildlife

April 24, 2026
Author(s)
Sally Bornbusch, Carly Muletz Wolz
Microbial ecology is increasingly incorporated into human and animal medicine via the study and purposeful manipulation of host-associated microbiomes. Microbial therapies – treatments with the aim of beneficially modulating microbiomes – are a burgeoning

Advancing forensic SNP typing: Insights from an interlaboratory study of the FORCE panel

April 21, 2026
Author(s)
Andreas Tillmar, Kimberly Andreaggi, Adam Staadig, Christina Amory, David Ballard, Erik Francisco Bergseth, Claus Borsting, Selena Cisana, Michael Coble, Lucinda Bella Davenport, Maria de la Puente, Katherine Gettings, Erin Gorden, Kelly Grisedale, Jennifer Daniels-Higgenbotham, Rachel Houston, Sheree HUGHES, Reet Jarving, Kevin Kiesler, Jonathan King, Maria Victoria Lareu, Odile Loreille, Dennis McNevin, Melissa Muenzler, Walther Parson, Vania Pereira, Christopher Phillips, Jorge Ruiz-Ramirez, Maarja Sadam, Jennifer Snedeker, Carolyn Steffen, Monika Stoljarova-Bibb, Peter Vallone, Jodie Ward, Jessica Watson, Catarina Xavier, Daniel Kling, Charla Marshall
This study evaluated the ability to produce FORensic Capture Enrichment (FORCE) genotypes using amplicon-based and capture-based enrichment assays. Fifteen laboratories from three different continents participated in this study, choosing from one of four

The Integration of Focused Ultrasonication, ddPCR, and Flow Cytometry Effectively Estimates Genome Copies per Cell and Enhances DNA Extraction Efficiency in Escherichia coli Samples

April 16, 2026
Author(s)
Sandra Da Silva, Nancy Lin, Kirsten Parratt, Hariharan Iyer, Guilherme Pinheiro, Holly Hack, Ian Hines, Stephanie Servetas
Microbiology researchers rely on nucleic acid measurement techniques, such as the quantitative polymerase chain reaction (qPCR) and DNA sequencing, to address diverse scientific and practical challenges. These applications range from detecting microbial

Serum proteome of the Egyptian rousette bat (Rousettus aegyptiacus) reveals signatures of immunity, proteostasis, and metabolism

April 6, 2026
Author(s)
Brooke Genovese, Nistara Randhawa, Benjamin Neely, Gabriela Grigorean, Amy Schuh, Brian Amman, Jessica Elbert, Simon Anthony, Jonna Mazet, Jonathan Towner, Brian Bird
Bats are increasingly studied for their ability to coexist with diverse viruses of human health importance. While this focus has yielded insights into host–pathogen dynamics, baseline physiological data from healthy bats remain limited, constraining

Result harmonization in medical laboratories: accomplishments and challenges.

March 13, 2026
Author(s)
Tony Badrick, Ralf D. Josephs, Liesbet Deprez, Christa Cobbaert, VINCENT DELATOUR, Christian Vogl, Katleen Van Uytfanghe, Ashley Green, Sverre Sandberg
The Joint Committee for Traceability in Laboratory Medicine was established in 2002 in response to the implementation of the European Community Directive 98.79/EC on in vitro medical devices. The Committee consisted of representatives from the

Advancing evanescent light scattering microscopy for single-particle characterization of gene delivery nanoparticles

March 4, 2026
Author(s)
Jagat Budhathoki, Gregory Cooksey, Matthew DiSalvo, Thomas Germer, Peter Bajcsy, Edward Kwee, Aaron Goldfain, Alexander Peterson
Precise and reproducible single-nanoparticle characterization is essential for advancing gene therapy, where viral vectors encapsulating therapeutic genes must be evaluated under formulation-relevant conditions. We present a label-free optical platform

How "pro" are probiotics for wildlife species? Novel data, lack of evidence, and future directions

February 28, 2026
Author(s)
Sally Bornbusch, Piper Thacher, Marlitza Francisque, Alexandra DeCandia, Robyn Bortner, Della Garelle, Erin Kendrick, Michael Maslanka, Carly Muletz Wolz
Treatments that aim to purposefully manipulate host-associated microbiomes are now prevalent in human and animal medicine. Probiotics that contain live bacteria are purported to improve microbiome function and host health. Although research is advancing
Displaying 1 - 25 of 1297
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