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Displaying 1 - 25 of 75

Drug Detection, Analysis, and Monitoring Workshop Report

August 30, 2024
Author(s)
Edward Sisco
This report is a summary of a workshop convened to capture the analytical and data challenges inherent to the detection, identification, and monitoring of illicit drugs in the United States – specifically highlighting current practices, challenges, and

Cannabis Laboratory Quality Assurance Program: Exercise 2 Cannabinoid Final Report

June 25, 2024
Author(s)
Andrea Yarberry, Melissa M. Phillips, Walter Brent Wilson
NIST launched a Cannabis Laboratory Quality Assurance Program (CannaQAP) in 2020 to assist laboratories in demonstrating and improving cannabis (hemp and marijuana) measurement comparability and competence. CannaQAP provides tools that allow analysts and

Characterization of Reference Material 8210: Hemp Plant

June 20, 2024
Author(s)
Colleen E. Bryan Sallee, Walter Brent Wilson, Charles Barber, Monique Johnson, Jenna Klingsick, Jerome Mulloor, Blaza Toman, Elena Wood, Laura Wood, Andrea Yarberry
The National Institute of Standards and Technology (NIST) Reference Material (RM) 8210 Hemp Plant delivers non certified values for cannabinoids and toxic elements in a dried ground hemp plant material to help cannabis and forensic laboratories for use as

National Institute on Drug Abuse Clinical Trials Network Meeting Report: Managing Patients Exposed to Xylazine-Adulterated Opioids in Emergency, Hospital and Addiction Care Settings

March 16, 2024
Author(s)
Jeanmarie Perrone, Rachel Haroz, Joseph D'Orazio, Giacomo Gianotti, Jennifer Love, Matthew Salzman, Margaret Lowenstein, Ashish Thakar, Stephanie Klipp, Lisa Rae, Megan Reed, Edward Sisco, Rachel Wightman, Lewis Nelson
Used as a veterinary sedative and not approved for human use, xylazine has been increasingly linked with opioid overdose deaths in the United States. A growing number of people have been exposed to xylazine in the illicit opioid supply (especially fentanyl

Determination of D9-THC, THCA, D8-THC, and total D9-THC in 53 Smokable Hemp Plant Products by Liquid Chromatography and Photodiode Array Detection

January 8, 2024
Author(s)
Walter Brent Wilson, Aaron Urbas, MARYAM ABDUL-RAHMAN, Arianna Romares, Ewelina Mistek-Morabito
The passage of the 2018 Farm Bill has led to an estimated value of $824M for hemp production in the United States (US) in 2021 with an approximately 76% of it focused on floral hemp that is used to produce hemp-derived finished products such as smokable

Inferring the nominal molecular mass of an analyte from its electron ionization mass spectrum

August 23, 2023
Author(s)
Arun Moorthy, Anthony J. Kearsley, William Mallard, William E. Wallace, Stephen E. Stein
The performance of three algorithms for predicting nominal molecular mass from an analyte's electron ionization mass spectrum is presented. The Peak Interpretation Method (PIM) attempts to quantify the likelihood that a molecular ion peak is contained in

On the challenge of unambiguous identification of fentanyl analogs: exploring measurement diversity using standard reference mass spectral libraries

July 11, 2023
Author(s)
Arun Moorthy, Edward Erisman, Anthony J. Kearsley, Yuxue Liang, Edward Sisco, William E. Wallace
Fentanyl analogs are a class of designer drugs that are particularly challenging to unambiguously identify due to the mass spectral and retention time similarities of unique compounds. In this paper, we use agglomerative hierarchical clustering to explore

Rapid Analysis of Drugs: A Tool to Detect Drug Overdose Spikes, Build Trust Among People Using Drugs and Reduce Overdoses - Maryland, November 2021 - August 2022

April 28, 2023
Author(s)
Erin Russell, Edward Sisco, Allison Thomson, Jasmine Lopes, Dana Heilman, Margaret Rybak, Malik Burnett, Meghan Appley, Matthew Gladden
Maryland overdose deaths increased 16%, to a record high of 2,912 deaths during the 12-month period from July 2020 to June 2021. Illicitly manufactured fentanyl and/or fentanyl analogs* contributed to 84% of these overdose deaths.† Timely public health

Development & Validation of A Rapid GC-MS Method for Seized Drug Screening

February 15, 2023
Author(s)
Madeline Bloom, Edward Sisco, Ira Lurie
Controlled substances are one of the most frequently analyzed types of evidence in forensic laboratories. An increase in frequency of seizures in recent years has necessitated a need for rapid screening techniques to decrease case backlogs and expedite

Field-Deployable Devices

January 1, 2023
Author(s)
Thomas P. Forbes, Raychelle Burks
Reductions in instrument size, weight, and power continue to facilitate the development and application of field-deployable devices for investigative purposes. Portable analytical instrumentation supporting the rapid and reliable identification of two

Cannabis Laboratory Quality Assurance Program: Exercise 2 Moisture Final Report

November 29, 2022
Author(s)
Chuck Barber, Colleen E. Bryan Sallee, Carolyn Burdette, Shaun Kotoski, Melissa M. Phillips, Walter Brent Wilson, Laura Wood
In 2020, NIST launched Cannabis Laboratory Quality Assurance Program (CannaQAP) to improve the comparability of the analytical measurements of cannabis and cannabis-derived products in forensic and cannabis (hemp and marijuana) testing laboratories
Displaying 1 - 25 of 75