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Material Measurement Laboratory

Biomolecular Measurement Division

Projects/Programs

Displaying 26 - 45 of 45
NIST MS Search 2

Monoclonal Antibody Mass Spectral Libraries

Ongoing
Intended Impact Modern mass spectrometers used in the field of proteomics and glycomics are capable of profiling hundreds, and even thousands of molecules in a single experiment. Each of these compounds is isolated and fragmented to form a mass spectrum. Therefore, interpretation of these mass

Nanocalorimetry

Ongoing
The global market for semiconductor chips is $270 billion. Growth in this industry is driven by the need to enhance performance by packing more transistors into the same chip area, with a relationship between feature size and time that approximately follows Moore's Law. As the feature size shrinks
Montage of photographs depicting eggs, almonds, grain, milk, strawberries, fish, peanuts, and soybeans.

NIST Food Protein Allergen Program

Ongoing
Food allergen management is an increasingly important economic and public health concern; therefore, accurate and reliable allergen measurements are a crucial component of the management pathway. Traditional methods for food allergen detection are based on immunoassay techniques and are linked to a
photo collage of meats, cheese, eggs, fish, and shellfish

NIST Food Safety Program

Ongoing
The Food Safety Program at the National Institute of Standards and Technology (NIST) provides advanced analytical chemistry and quantitative biology to ensure that food is free of contaminants and allergens and is authentic, promoting U.S. manufacturers’ participation in domestic and foreign markets

NIST Monoclonal Antibody Reference Material 8671

Ongoing
The NISTmAb material is a recombinant humanized IgG1κ expressed in murine suspension culture. It is an »150 kDa homodimer of two identical light chains and two identical heavy chains linked through both inter- and intra-chain disulfide bonds. The protein has low abundance post-translational
Image of a fentanyl mass spectrum shown in a lab notebook

NIST and the SWGDRUG Mass Spectral Reference Library of Seized Drugs

Ongoing
Synthetic drugs such as fentanyl and its analogues are driving an unprecedented epidemic of overdose deaths in the United States. Clandestine labs create these new substances in part to evade law enforcement. This places a major burden on federal, state, and local law enforcement agencies to
Reference Measurement System for Urine Albumin

NIST Urine Albumin Standardization Program

Ongoing
Kidney disease is a major global economic and public health issue, with chronic kidney disease (CKD) representing one of the top 10 most prominent causes of death worldwide. The public health and economic impact of CKD and other kidney diseases has led to the need for the accurate detection of
Example unit of NIST Research Grade Test Material (RGTM) 10197 NISTCHO Test Material

NISTCHO

Ongoing
NISTCHO, a new mammalian cell line of interest to the biopharmaceutical and biomanufacturing communities, is now available from the National Institute of Standards and Technology. This Chinese hamster ovary (CHO) cell line has been engineered by MilliporeSigma to express a non-originator version of
schematic

Optical/electrical particle measurement system

Ongoing
Intended Impact The results of this work should provide instrument manufacturers with data, methods, and algorithms for enhancing the clarity and accuracy of information their instruments provide to their customers. Users of these instruments (pharma companies) and regulators, will have better

Peptide Mass Spectral Libraries

Ongoing
Intended Impact Modern mass spectrometers used in the field of proteomics are capable of profiling thousands of peptides in a single experiment. Each of these peptides is fragmented to form a mass spectrum. Therefore, interpretation of these mass spectra is a critical step in the experimental

Performance Metrics for Proteomics

Ongoing
Intended Impact Proteomics experiments designed to identify protein markers specific to a particular disease or disease state rely on repeatable identification of proteins within a control set. Repeatability provides statistical assurance that clear differences between two sets (e.g. sick vs
Epidemiologist in protective suit, mask and glasses works with patient swabs to detect specific region of 2019-nCoV virus causing Covid-19

SARS-CoV-2 Research Grade Test Material

Completed
In response to the COVID-19 pandemic, the National Institute of Standards and Technology released a synthetic RNA material for SARS-CoV-2 in June 2020. The goal was to rapidly produce a material to support molecular diagnostic testing applications. This material, referred to as Research Grade Test

Surrogate protein particle standards

Ongoing
Intended Impact This work will enable industry to obtain accurate, reproducible counts of protein particles, and to differentiate protein particles from other particle types, resulting in greater drug efficacy and safety. Objectives Create a polydisperse suspension of polymer particles that mimic

Tandem Mass Spectral Library

Ongoing
Intended Impact Modern mass spectrometers commonly generate ions by electrospray mass spectrometry which are separated and then fragmented by collisional dissociation. This process yields fragment ion ‘fingerprints’ (or mass spectra) that are widely used to identify the individual components in a

Targeting Membrane Proteins

Ongoing
Membrane proteins constitute approximately 30% of all cellular proteins. Nevertheless, this group of proteins is traditionally understudied due to limitations of the available analytical tools. Given the importance of membrane proteins in the various cellular processes and their potential as drug
BK_JC_plasmids

BK and JC Virus DNA Standard Reference Materials

Ongoing
Whole BKV or JCV virus genomes have been inserted into a cloning vector, propagated in Escherichia coli, extracted, linearized, and certified for number of copies of the genome per volume (e.g. copies per microliter). The DNA was sequenced and provided as information value in the certificate of