Projects/Programs

Displaying 1 - 25 of 32

Assessing the Environmental, Health and Safety Impact of Nanoparticles

Completed

Impact Nanomaterials have already been incorporated into a large range of commercial products including pharmaceuticals, sunscreens, automobile additives, personal care products, detergents and plastics. Although nanotechnology is changing the way we live, the accidental release of nanomaterials

Bioimaging

Completed

Imaging and image analysis are used ubiquitously in biological and biomedical research. One of the great advantages of imaging is its intuitive information content; much can be learned from just a glance at the data. On the other hand, these data generally contain a very large amount of untapped

Biosurveillance and Pathogen Detection

Ongoing

NIST has established partnerships with other federal agencies to develop standards and measurement solutions to support biosurveillance. These efforts are supported in part through interagency agreements with partner agencies listed below to address their standards needs. PROGRAMS Standards for

Cell-based Assay for Mechanistically-based Prediction of Cytoxicity

Completed

Ricin is a type 2 ribosome inactivating protein (RIP) belonging to the A-B family of toxins and is of particular interest because of its potential use as a biological weapon and the dearth of rapid and sensitive assays that could assist detection and decontamination. The ricin toxin inhibits protein

Characterization of Dolphin Lung Endothelial Cells Through Quantitative Imaging

Completed

Due to their characteristics (long life span, feed at a high trophic level, extensive fat stores that can act as a deposit for anthropogenic toxin) dolphins have been proposed as a good sentinel organism in aquatic and coastal environments to monitor and understand the impact of infectious diseases

Illustration of satellite sensing of sunlight reflected by buildings, roads, water and trees to assess radiative warming of the earth.

Climate Science

Ongoing

This program encompasses multifaceted efforts to advance the metrology of climate science. Projects include: development of ultra-high accuracy optical standards and technologies to determine greenhouse gases (GHGs) concentrations, atmospheric lifetimes, and aerosol radiative forcing development of

Comparing the Biological Responses of Photoluminescent Silicon Nanoparticles with Silicon Micron-sized Particles

Completed

Intended Impact Technology is now available to produce nanoparticles of uniform size and shape which may allow their use in a wide range of applications from drug delivery to water purification. The high surface area to volume ratio of nanoparticles makes them particularly good catalysts as well as

Photograph of SRM 2669 Arsenic Species in Frozen Human Urine, with vials and desiccant packs, and labeled mylar bag.

Development of SRM 2669 for Accurate Assessment of Arsenic Exposure

Ongoing

Arsenic exposure in the U.S. population is an important part of the NHANES program conducted by CDC because dietary exposure to arsenic can cause serious health effects. A major challenge in the arsenic exposure assessment is that arsenic exists as various species in nature, and the toxicity of

Development of SRM 955c Toxic Elements in Caprine Blood

Completed

Intended Impact Over the last three decades, NIST, with support from the Centers for Disease Control (CDC), and in conjunction with the New York State Department of Health’s (NYSDOH) Wadsworth Center, has produced a number of frozen whole blood certified reference materials containing endogenous

Development of SRMs 2668 and 3668 for Accurate Assessment of Exposure to Toxic Elements and Anions

Completed

Toxic elements in the environment are a threat to public health and safety. Federal and state regulations have been issued to limit and abate the presence of toxic elements in the environment. The levels of toxic elements in the U.S. population are carefully monitored. NHANES is one of the federal

Electron Ionization Library Component of the NIST/EPA/NIH Mass Spectral Library and NIST GC Retention Index Database

Ongoing

Intended Impact The speed and accuracy of chemical analyses are vital issues in many areas. Monitoring for explosives, drugs (both legal and illegal), chemical weapons, pollutants, petrochemical processing, food contamination, and health/disease status biomarkers is a challenge with a high reward in

Environmental Leaching of Nanoparticles from Consumer Products

Ongoing

New nanotechnology-based consumer products are currently entering the market at a rate of 3 or 4 per week, and it is estimated that $2.6 trillion in manufactured goods will contain nanotechnology by 2014. Unfortunately, the overall safety of short- and long-term exposure to nanoparticles and the

Environmental Metabolomics

Ongoing

The application of metabolomics techniques to environmental systems biology offers a promising opportunity to achieve insights into non-model organism biology. Each biological system manifests distinctive challenges that offer insights into criteria important for rigorous study design and method

Fundamental Interaction Mechanisms of Engineered Nanomaterials with DNA

Completed

Intended impact Nanotechnology research has resulted in the rapid creation of engineered nanomaterials with many foreseeable applications in medical imaging/diagnosis and in drug delivery. However, there is a notable scarcity of both acute and chronic human toxicity data for these new materials

Photograph of a seabird with a spotted turquoise egg.

Isotopes as Environmental Tracers in Biological Specimens

Ongoing

Multicollector inductively coupled plasma mass spectrometry (MC-ICP-MS) provides sensitive and precise measurements of stable isotope ratios and can be coupled to a variety sample introduction systems such as laser ablation and gas or liquid chromatography. The versatility and performance of MC-ICP

Measurement Techniques for Membranes and Membrane Proteins

Ongoing

Use of synthetic cell membrane mimics allow simplification and complete control of a complicated system, and incorporation of selected elements under physiological conditions. We are furthering a technology originally developed at NIST using model lipid membranes supported on surfaces for

Microcryocooler for Terahertz Detectors

Ongoing

DARPA has been interested in the development of cooled detector systems (infrared and terahertz) that require less than 1 W of input power (battery operated) and have a total volume less than about 4 cm 3. Such systems could be used for detection of enemy missile launches (infrared), chemical

Nanometrology: Composition and Structure of Nanomaterials

Ongoing

Pushing the Limits of Measurement Accuracy in Atom Probe Mass Spectrometry Nanoscale Analysis of Biological and Organic Materials Release from Nanocomposite Consumer Products

Nanoparticle Metrology in Complex Cellular Environments

Completed

Nanoparticle interactions with individual cells. Existing techniques to evaluate nanoparticle incorporation include ICP-AES or ICP-MS, which atomize entire samples (thousands of cells) and detect nanoparticles by quantifying the elemental composition. Bulk techniques provide general trends averaged

Nanotube Metrology

Completed

Single-wall carbon nanotubes (SWCNTs) are a tubular form of carbon consisting of a single shell of sp2 bonded carbon with a nanometer scale diameter that have many predicted properties superior to other available materials. However, every production technique for SWCNTs produces many different

NCNR DAC and CCUS efforts

Ongoing

Objectives To advance US competitiveness in Direct Air Capture (DAC) and Carbon Capture, Usage, and Sequestration (CCUS) Use advanced neutron scattering techniques to understand the adsorption process for the most promising materials for adsorption-based carbon capture and provide avenues to

NIST23: Updates to the NIST Tandem and Electron Ionization Spectral Libraries

Ongoing

NIST Tandem Mass Spectral Library, 2023 release 51,501compounds 60% increase over the 2020 release 399,267 precursor Ions 2.4 million spectra Fragmentation methods 49,590 HRAM (high res accurate mass) compounds 51,292 QTOF, HCD, IT-HRAM, QqQ compounds 49,561 ion trap compounds (low res., up to MS 4)

Organic Contaminants in Human Serum, Milk, and Urine

Ongoing

SRMs have been developed to support quality assurance measurements for contaminants in human fluids. Biomonitoring laboratories will use these SRMs to validate methods and as control materials for specific analyses. We have developed and characterized several human-matrix SRMs for organic

Photo montage with images of a sea turtle, sea lion, whale, and dolphins.

Pacific Marine Mammal Health Assessments (PMMHA)

Ongoing

Pacific Marine Mammal Health Assessments (PMMHA), which began in Fall 2010, are an expansion of NIST marine mammal health assessment collaborations that began in 2002 with bottlenose dolphin wild populations. NIST has a history of involvement in marine mammal health assessment related work

Photo montage showing fill the airplane with fire-fighting foam, a spilled glass of wine on the tablecloth. Cleaning clothes and furniture from stains, Discarded Fast Food Wrappers Littered on Ground, wateproof jacket with water droplets on it. Jacket using the gore-tex technology.

Per- and Polyfluoroalkyl Substances (PFAS)

Ongoing

Perfluorinated and polyfluorinated alkyl substances (PFAS) constitute a family of compounds that are distinguished by partial or complete fluorination of alkyl hydrocarbons. Dubbed “forever chemicals”, the unique chemistry of PFAS imparts a high level of stability, making the compounds resistant to

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