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Material Measurement Laboratory

Projects/Programs

Displaying 76 - 100 of 566
Photograph of a unit of RM 8027 Silicon Nanoparticles (Nominal Diameter 2 nm) showing a labeled box and ampoules.

Chemical Characterization of Nanoparticles

Ongoing
NIST has a broad research program spread throughout the major operating units aimed at building the supporting technical capabilities that U.S. industry needs in their quest to develop new nanotech products with desirable new capabilities and bring them safely to market. The Chemical Sciences
Cannabis Buds

Chemical Foundations for a Cannabis Breathalyzer

Ongoing
NIST's initial work in cannabis science was a series of measurements of the vapor pressure of two important cannabinoids: delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). Our current effort is funded in part by interagency agreements with the National Institute of Justice and by the NIST
Photograph of titanium metal crystal with cubic symmetry.

Chemical Metrology for Metals, Ores, and Related Materials

Ongoing
In the arena of industrial commodities, the primary challenges are to provide measurement tools and reference materials that allow U.S. industry to establish comparability of measurement results to results obtained by customers, competitors, and regulators for the basic chemical properties of
Photograph of three labeled bottles of SRM 2855 containing low-density and high density polyethylene

Chemical Metrology for Polymers Manufacturing

Ongoing
This project is designed to strengthen the analytical capabilities of polymers manufacturers by introducing reference materials, critically evaluating standard test methods, and educating those industry representatives who participate in standards development organizations. Certified reference
CHO dna str profile

Chinese hamster ovary (CHO) cell line authentication

Ongoing
Intended impact To develop a PCR based multiplex assay that can be used to authenticate Chinese hamster ovary cell lines which are important in the production of biological therapeutics. Objectives Identify tetranucleotide STR markers by searching the CHO genome using BLAST Design and optimize a
Map of the Northern hemisphere Pacific Ocean, with environmental specimen sampling sites indicated with data points in the Hawaiian Islands, Alaska, and Bering Sea locations.

Classification Methods for the NIST Biorepository

Ongoing
NIST has been archiving biological and environmental specimens, including marine animal and environmental samples, for over 40 years. Currently, these biospecimens are stored at cryogenic temperatures in the NIST Biorepository located at the Hollings Marine Laboratory in Charleston, SC. Various
Illustration of satellite sensing of sunlight reflected by buildings, roads, water and trees to assess radiative warming of the earth.

Climate Science

Ongoing
This program encompasses multifaceted efforts to advance the metrology of climate science. Projects include: development of ultra-high accuracy optical standards and technologies to determine greenhouse gases (GHGs) concentrations, atmospheric lifetimes, and aerosol radiative forcing development of

Clinical and Forensic Reference Materials

Ongoing
Below is a listing of the reference materials currently produced by the Applied Genetics group. Clinical Diagnostics SRM 2393 - CAG Repeat Length Mutation in Huntington`s Disease SRM 2365 - BK Virus DNA Quantitative Standard SRM 2366a - Cytomegalovirus DNA (Towne Δ147 BAC) for DNA SRM 2367 - JC
Photograph of a unit of SRM 3950 showing a labeled box and two frost covered amber bottles.

Clinical Measurements Quality Assurance Program

Ongoing
The National Institute of Standards and Technology (NIST) established the Clinical Measurements Quality Assurance Program (ClinQAP) to support the measurement needs of the clinical community. Participants measure concentrations of marker compounds, contaminants, metabolites in clinical samples (e.g
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Cloud of Reproducible Records

Ongoing
Cloud of Reproducible Records (CoRR) CoRR is a Cloud Infrastructure for storing, disseminating, federating and collaborating on Reproducible Record atoms. It is composed of two Python Flask REST web services (Cloud and API), a cloud storage space, a MongoDB database and a Material Design AJAX web

Combating Antibiotic Resistance

Ongoing
We are developing in vitro systems to generate controlled chemical and community environments that mimic the features of real-world that are important determinants for evolutionary rate and resistance potential. In addition, we are developing tools to isolate and analyze single bacteria along the

Combinatorial Approaches to Thin Film Nanomaterials

Completed
The behavior and performance of nanostructured materials and devices are governed by the chemistry and structure of their surfaces and interfaces. However, chemistry-structure-performance relationships in these systems are complex, so hundreds of experiments can be necessary to determine optimal
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Comparative Mammalian Proteome Aggregator Resource (CoMPARe) Program

Ongoing
Comparative proteomics strives to gain insight into key underlying molecular changes that result in unique phenotypes across related taxa. Proteomic analysis complements comparative genomics by providing evidence of protein abundance, orthogonal to gene copy number and amount of transcript. To
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Comparative Serum Proteomics Project

Ongoing
State-of-the-art biomolecular analysis is no longer limited to model organisms and is becoming routine in non-model organisms. Major drivers of this emerging bioanalytical capacity include increasing accessibility and quality of sequenced genomes as well as high-resolution fast-duty cycle mass

A Comparison of WD-EPMA Heterogeneity Testing Procedures

Ongoing
X-ray stage mapping (XSM) can be used to determine the extent of heterogeneity on the micron scale though it is more time consuming and not as accurate as the more rigorous NIST random-point (RP) testing procedure. The objective of this work is to demonstrate the advantage of the latter procedure
IPython Automation

Complete Automation and Distribution of Parallel Simulation Tasks

Ongoing
In computational materials science, many problems require the execution of numerous parallel simulation tasks on High Performance Computing (HPC) resources. Often a single published data point is the result of several parallel tasks executed in a specific sequence. Despite the continual improvement
Illustration of cyberbrain surrounded by industry icons

Computation Platform for AI/ML

Ongoing
In collaboration with NIST’s Information Technology Laboratory and Office of Information Systems Management, the Office of Data and Informatics is supporting the deployment and development of the long-term operational model for the enki computation platform for NIST staff members who research and
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Computational Design of Photopolymerized Materials

Ongoing
Photopolymerization represents a versatile method that affords rapid and robust manufacturing of polymers and composites. The properties of polymerized materials can be controlled by the chemistry and processing parameters, as well as novel molecular mechanisms. As such, photopolymerization has
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Consistency Analysis and Uncertainty in ‘omic Data

Ongoing
‘Omics is increasingly moving out of the laboratory and towards use in industrial and commercial applications. For instance, in biomanufacturing, there is a need for quality control when developing biotherapeutics, which will almost certainly require a machine-learning classifier to separate
Photograph of SRM 114r Portland Cement Fineness Standard showing labeled mylar bag and vial.

Continuing Support of Cement Manufacturing

Ongoing
NIST SRMs for Portland cement and related materials are the de facto world standards for validation of analytical methods for testing of cement for compliance with manufacturing specifications and for qualification of laboratories throughout the supply chain, including cement plants, construction
Cover of the ASME International Steam Tables for Industrial Use, Third Edition

Contributions to International Standards on the Properties of Water

Ongoing
Water is probably the most widely used industrial fluid and it is important to have internationally accepted standards for its properties. This information is crucial to the analysis and design of thermal power cycles, as well as for climate studies including the hydrosphere. (Here is a summary of

Controlling Microfluidic Cell Cultures

Completed
Intended impact: Cell behavior is powerfully modulated by local extracellular cues. However, the number of parameters that affect cell behavior is large, and include soluble signaling molecules, dissolved gases, the chemistry and mechanics of the extracellular matrix, and the proximity and behavior