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Cellular Engineering Group

The Cellular Engineering Group works to provide a foundation of measurement assurance to support the control and rational design of biological function.

New measurement methods and tools are required for biology to emerge fully as an enabling, practical platform for engineering. The Cellular Engineering Group works to provide a foundation of measurement assurance to support the control and rational design of biological function. Through state of the art synthetic biology, automation, and machine learning, the Group creates living measurement systems, such as cells, engineered to sense and respond in programmed ways. Importantly, building these systems both requires and advances meaningful quantitation of the effects of environmental context and evolution. The Group aims to advance fundamental understanding, improve predictability for design, ensure reproducibility and comparability, and facilitate scalability for real-world applications of engineered biological systems.

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Using enantioselective biosensors to evolve asymmetric biocatalysts

Author(s)
d’Oelsnitz Simon, Wantae Kim, Haley Hardtke, Svetlana Ikonomova, Nina Alperovich, Olga Vasilyeva, Michael James, Eric Zigon, Charlie Johnson, Andrew Ellington, Quincey Justman, Michael Springer, Jessie Zhang, Pamela Silver, David Ross
Biocatalysts are championed for their exquisite stereochemistry, but slow chromatographic separations necessary to measure enantiomeric excess can bottleneck

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NRC Postdoctoral Fellowship opportunities

Professional Research Experience Program (PREP)

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